Surgical options to preserve ovaries in girls and adolescents with simple ovarian cysts
Official title: Save the Ovaries - Surgical Management of Simple Ovarian Cysts in Children and Adolescents
Run by University Children's Hospital, Zurich · NCT06852313 · Data updated 2026-11-12
This trial will see if laparoscopic cyst enucleation or laparoscopic cyst deroofing better preserves ovarian reserve and lowers cyst recurrence in girls and adolescents with simple ovarian cysts.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 1 Year to 18 Years |
| Sex | Women only |
| Enrollment | 80 (estimated) |
| Sponsor | University Children's Hospital, Zurich Academic / other |
| Locations | 2 sites (Basel and 1 other locations) |
| Status | Recruiting |
| Started | February 5, 2026 |
| Main results expected | April 1, 2028 |
| Study ends | December 1, 2028 |
| Registry record updated | April 28, 2026 |
| Trial ID | NCT06852313 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are girls and adolescents aged 12 months to 18 years with simple ovarian cysts ≥4 cm that require surgery, with parental consent and appropriate language ability.
✕Probably not a fit
Patients younger than 12 months, those with complex or suspicious cysts, paraovarian cysts, or medical contraindications to enucleation are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Girls and adolescents (12 months to 18 years) with symptomatic or persistent simple ovarian cysts of 4 cm or larger will undergo one of two laparoscopic procedures: cyst enucleation or cyst deroofing. Investigators will follow ovarian function markers and monitor for cyst recurrence after surgery. The study focuses on surgical technique choice and its effects on ovarian reserve and the likelihood of cyst coming back. Enrollment and procedures take place at pediatric surgical centers in Zurich and Basel.
Why it matters
Potential benefit: If successful, the results could help surgeons choose the technique that best preserves ovarian function and reduces repeat operations for young patients.
How similar studies have gone: Laparoscopic enucleation and deroofing have been used in adults and reported in pediatric case series, but high-quality comparative data specifically in children and adolescents remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic simple cysts ≥ 4 cm with indication for surgical intervention * Asymptomatic cysts ≥ 4 cm, with surgical indication due to persistence or increase in size * Asymptomatic cysts ≥ 4 cm with other pathology as surgical indication, if known preoperatively * Age 12 months - 18 years * Parents/legal custodian and patient give consent, for patients unable to consent due to their health condition or developmental status they show no signs of unwillingness to participate * Symptomatic simple cysts ≥ 4 cm with indication for surgical intervention on both ovaries (each ovary will count as one) Exclusion Criteria: * Neonatal ovarian cysts (age \<12 months) * Age \>18 years * Complex cysts (with solid components, e.g., Teratoma, risk or suspicion of malignancy) * Paratubar/paraovarian cysts * Medical reason that precludes cyst enucleation (e.g. severe coagulopathy) * Neither signed informed consent form or inadequate german, french or english language skills to give informed consent
Where it's running
-
University Children's Hospital Basel
Basel, Switzerland Recruiting -
University Children's Hospital Zurich
Zurich, Switzerland Recruiting
Study contacts
- Study coordinator: Uchenna Kennedy, MD
- Email: uchenna.kennedy@kispi.uzh.ch
- Phone: 0041 2494949
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.