Surgical options for treating irreducible atlantoaxial dislocation
Official title: A Randomized Controlled Study for Surgical Treatment of Irreducible Atlantoaxial Dislocation
Run by Peking University Third Hospital · NCT05847270 · Data updated 2026-11-12
This study is testing two different surgical methods to see which one works better for people with a serious neck condition called irreducible atlantoaxial dislocation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 80 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | July 11, 2023 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | January 8, 2024 |
| Trial ID | NCT05847270 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 0 to 80 years diagnosed with irreducible atlantoaxial dislocation who are eligible for surgical intervention.
✕Probably not a fit
Patients with significant comorbidities, critically ill conditions, or those who decline participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the safety and effectiveness of two surgical approaches for irreducible atlantoaxial dislocation (IAAD): a simple posterior approach and a combined anterior and posterior approach. The study will involve 260 patients who will be randomly assigned to one of the two surgical groups. Comprehensive assessments will be conducted, including radiological evaluations and tracking of neurological function improvements over a 12-month follow-up period. The goal is to determine the optimal surgical strategy for managing IAAD and to establish diagnostic and treatment standards.
Why it matters
Potential benefit: If successful, this study could lead to improved surgical outcomes and standardized treatment protocols for patients with irreducible atlantoaxial dislocation.
How similar studies have gone: While there is ongoing debate regarding surgical approaches for IAAD, this study aims to provide high-level evidence that may clarify the optimal treatment strategy, making it a potentially novel contribution to the field.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Eligible participants encompass individuals within the age range of 0 to 80 years, without regard to gender. 2. Patients who have received a diagnosis of irreducible atlantoaxial dislocation (IAAD) based on preoperative imaging and skull traction evaluation, with a traction weight equivalent to 1/6 of their body weight following anesthesia. These patients are candidates for surgical intervention. 3. Participants who have provided informed consent either in person or through their legal representative (the principal). Exclusion Criteria: 1. Individuals with concomitant medical conditions or diseases that significantly impact surgical treatment, such as malignant metastasis or infectious diseases, will be excluded from the study. 2. Critically ill patients, who are not suitable candidates for surgical intervention, will also be excluded. 3. Patients who actively decline to participate in this research project will not be included in the study cohort.
Where it's running
-
Peking University Third Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Shenglin Wang, MD
- Email: pkuwsl@126.com
- Phone: +86 13501380281
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.