Surgical joint denervation for painful digital osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial evaluates the effectiveness of surgical joint denervation as a treatment for painful digital osteoarthritis, a condition characterized by severe pain and functional impairment in the hands. The study focuses on patients with symptomatic osteoarthritis who have not responded to conventional medical treatments. By cutting the nerve branches supplying the affected joints, the trial aims to alleviate pain and improve function. The study is prospective and aims to gather data on the outcomes of this surgical intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Patients with symptomatic digital osteoarthritis according to the criteria of the American College of Rheumatology
* 1 painful PIP joint (Analog digital scale ≥ 4/10) for more than 3 months
* having failed the usual medical treatment for a minimum of 3 months (level 1 analgesics, NSAIDs, infiltrations)
* Signature of informed consent
* patient affiliated to a social security scheme
* knowing how to read French (for the questionnaires)

Exclusion Criteria:

* digital osteoarthritis secondary to other known causes (eg gout, reactive arthritis, RA, psoriatic arthritis, spondyloarthropathies, septic arthritis)
* anesthetic contraindications to surgery or to performing an MRI
* Existence of a pain syndrome in the upper limbs, which would interfere with the assessment of AD.
* Fibromyalgia
* Use of oral, intramuscular or intra-articular or intravenous corticosteroids, immunosuppressants (methotrexate, sulfasalazine, leflunomide, biomedicines), hyaluronic acid infiltration in the finger joints in the previous month
* Introduction of a new treatment for osteoarthritis of the hand in the previous month, including physiotherapy and fitting of a new finger orthosis.
* History of denervation of the proximal interphalangeal joint (PIP)
* Patient under legal protection (guardianship or curatorship) and patient deprived of liberty
* Patient under AME
* Participation in another interventional research involving the human person or period of exclusion at the end of a previous research involving the human person.

Where it's running

• Rheumatology department Saint-Antoine Hospital
  Paris, France Recruiting

Study contacts

• Principal investigator: Jérémie SELLAM — Assistance Publique - Hôpitaux de Paris
• Study coordinator: Adeline CAMBON-BINDER, MD PhD
• Email: adeline.cambonbinder@aphp.fr
• Phone: 685573795

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-dose radiotherapy versus corticosteroid injection for hand and wrist osteoarthritis

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• Evaluating the CapFlex PIP implant for osteoarthritis in the hand

  This study is testing how well the CapFlex PIP implant works for people with osteoarthritis in their finger joints over 10 years.

  Recruiting Reinier Haga Orthopedisch Centrum · Zoetermeer, South Holland · NCT05484089

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.