Surgical fixation for hip fractures in patients on blood thinners
Early Surgical Fixation of Low-Velocity Hip Fractures in Patients With Direct Oral Anticoagulation
This study is testing if fixing hip fractures quickly in patients on blood thinners can reduce blood loss and improve survival rates compared to those who have surgery later.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 140 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna) |
| Trial ID | NCT05070169 on ClinicalTrials.gov |
What this trial studies
This study examines patients with intertrochanteric hip fractures who are receiving direct oral anticoagulation (DOAC) therapy and undergo early surgical fixation within 24 hours of injury. The primary goal is to evaluate the reduction in perioperative blood loss associated with early fixation. Additionally, the study aims to assess the impact of early surgical intervention on 30-day and 1-year mortality rates compared to a control group that received delayed fixation. The cohort will be compared to a matched group of patients who had delayed surgery from 2014 to 2018.
Who should consider this trial
Good fit: Ideal candidates are patients with intertrochanteric fractures requiring surgical fixation while on DOAC medication.
Not a fit: Patients with multiple fractures or significant comorbidities that prevent prompt surgical fixation may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to reduced blood loss and improved survival rates for patients with hip fractures on anticoagulation therapy.
How similar studies have performed: While similar studies have explored surgical timing in fracture management, this specific approach in patients on DOAC therapy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Prospective cohort study: Patients with intertrochanteric fractures that need a surgical fixation and under treatment with a DOAC medication Control group: Patients with intertrochanteric fractures under DOAC medication with a delayed surgical fixation from January 2014 to December 2018 (≥ 48 hours after the trauma) Exclusion Criteria: Prospective cohort group: * patients with multiple fractures * acute heart failure, kidney and lung failure and * other concomitant diseases which prevent prompt fixation Retrospective cohort group: Patients with delayed surgical fixation due to other causes than DOAC medication (e.g. multimorbidity, acute myocardial infarction, acute heart, lung or kidney failure)
Where this trial is running
Vienna
- Medical University of Vienna, Department of Traumatology — Vienna, Austria (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.