Surgery with fat grafting for Dupuytren's disease recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of adding autologous adipose tissue grafting to the standard surgical treatment of Dupuytren's disease, known as aponeurectomy. The study aims to compare recurrence rates of Dupuytren's disease in patients who undergo aponeurectomy with and without the fat grafting procedure. The hypothesis is that the adipose tissue may inhibit the recurrence of fibrosis and improve scar quality. The trial will involve a prospective comparative approach with a control group and an experimental group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Carrier of Tubiana stage II-IV Dupuytren's disease on at least one or more rays, not previously operated
* Indication of a surgery by aponeurectomy
* Skin pinch of the posterior aspect of the arm of more than 1cm
* Affiliation to a social security system
* Patient informed of the study and having given informed consent

Exclusion Criteria:

* Previous surgery of any kind for Dupuytren's disease
* Involvement on the thumb only
* Need for a total skin graft or a pedicle flap on all the rays to be treated
* Active autoimmune disease
* Previous treatment with collagenase
* Pregnant and breastfeeding women
* Patient under legal protection
* Contraindications to MRI (criteria applicable only for patients from the coordinating center, not applicable for other centers)

Where it's running

• Institut Aquitain de la Main
  Pessac, France Recruiting
• Santé Atlantique ELSAN
  Saint-Herblain, France Recruiting

Study contacts

• Principal investigator: Elias SAWAYA, MD — Institut Aquitain de la Main
• Study coordinator: Elias SAWAYA, MD
• Email: esawaya.md@gmail.com
• Phone: (0)663420278

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Treatment for early Dupuytren's disease using vitamin E cream

  This study is testing if using vitamin E cream can help people with early Dupuytren's disease stop their fingers from getting worse.

  Recruiting Phase 2 Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06321991

• Investigating the role of micronerves in Dupuytren's disease and their impact on recurrence

  This study looks at whether tiny nerve bundles in the hand affect how often Dupuytren's disease comes back after surgery in people with this condition.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06142929

• Treatment options for Dupuytren's contracture

  This study is testing whether adding a corticosteroid injection to a needle treatment helps people with Dupuytren's contracture move their fingers better.

  Recruiting Phase 4 Regionshospitalet Silkeborg · Silkeborg · NCT05440240

• Evaluating night splinting after needle fasciotomy for Dupuytren's contracture

  This study is testing if wearing a night splint after a needle procedure for Dupuytren's contracture can help prevent the condition from coming back compared to just physical therapy alone.

  Recruiting at 3 sites Uppsala University · Falun, Dalarna County and 2 other locations · NCT05300893

• Evaluating post-surgery radiation treatment for Dupuytren's disease

  This study is testing whether adding radiation treatment after surgery for Dupuytren's disease can help improve hand function and reduce symptoms for patients.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT04122313

• CNT201 collagenase injection for Dupuytren’s: safety and signals of efficacy in adults

  A randomized, placebo-controlled study will test CNT201 injections to see if they are safe and help improve finger contractures in adults with Dupuytren’s disease.

  Recruiting Phase 1/2 Connext · Kippa-Ring, Queensland · NCT07640425

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.