Surgery to improve treatment for Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the safety and efficacy of deep cervical lymphatic-venous anastomosis (dcLVA) surgery in patients diagnosed with Alzheimer's disease. Participants will be randomly assigned to receive either the dcLVA surgery combined with standard medication or standard medication alone. The study will involve cognitive assessments, brain MRI scans, and lumbar punctures to measure changes in cognitive function and glymphatic clearance over a 12-month period. The primary outcome will be assessed using the Clinical Dementia Rating Scale scores.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed as an AD patient according to biological markers and clinical symptoms;
* Over 35 years old and with an MMSE or MOCA score ≤ 26;
* The patient or family member has signed an informed consent form.

Exclusion Criteria:

* Inability to cooperate with lumbar puncture;
* Cognitive impairment due to neurological infections (e.g., HIV, neurosyphilis, autoimmune encephalitis) or systemic diseases (e.g., diabetes, thyroid dysfunction);
* Significant organ dysfunction (heart, lung, liver, kidney);
* Coagulation disorders or contraindications to surgery;
* Inability to fully cooperate with follow-up visits.

Where it's running

• Zhejiang Provincial People's Hospital
  Hangzhou, Zhejiang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.