Suction curettage versus hysteroscopy for early pregnancy loss after IVF
Official title: Comparison Of Surgical Management Of Early Pregnancy Loss By Suction Curettage Versus Hysteroscopy In Patients Undergoing In-Vitro Fertilization (IVF)
Run by Assaf-Harofeh Medical Center · NCT07143578 · Data updated 2026-11-12
This trial will test whether hysteroscopy or suction curettage is better for removing early pregnancy loss in people who conceived with IVF.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | Assaf-Harofeh Medical Center Government |
| Locations | 2 sites (Be’er Ya‘aqov and 1 other locations) |
| Status | Recruiting |
| Started | August 20, 2025 |
| Main results expected | August 30, 2026 |
| Study ends | August 30, 2027 |
| Registry record updated | January 27, 2026 |
| Trial ID | NCT07143578 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with an early pregnancy loss (≤10 weeks) conceived via IVF who can provide informed consent, read Hebrew, and do not have heavy bleeding, signs of infection, uterine anomalies, prior intrauterine adhesions, or disqualifying surgical histories.
✕Probably not a fit
Patients with heavy vaginal bleeding or incomplete abortion, suspected infection, known uterine anomalies, prior intrauterine adhesions, a history of ≥3 miscarriages or ≥3 cesarean sections, prior myomectomy, prior treatment for the current pregnancy, or those who did not conceive via IVF are unlikely to benefit or are not eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares operative hysteroscopy using a tissue removal device with conventional suction curettage for evacuation of early pregnancy loss up to 10 weeks in individuals who conceived via IVF. Participants will undergo one of the two surgical procedures and be followed for outcomes such as retained products, bleeding, operative time, and the development of intrauterine adhesions. Hysteroscopy provides direct visualization of the uterine cavity and targeted tissue removal, while suction curettage is performed without direct vision. The trial aims to determine whether hysteroscopy reduces adhesion rates and other complications without causing unacceptable increases in operative time or other risks.
Why it matters
Potential benefit: If successful, hysteroscopy could reduce intrauterine adhesions and lower the risk of complications that might impair future fertility after early pregnancy loss.
How similar studies have gone: Previous studies, including a randomized trial, showed substantially lower rates of intrauterine adhesions after hysteroscopy compared with suction curettage, although hysteroscopy was associated with longer operative time.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Diagnosis of early pregnancy loss up to 10 weeks' gestation, based on last menstrual period or ultrasound. 2. Pregnancy conceived through assisted reproductive techniques (in vitro fertilization, IVF). 3. Ability to provide informed consent, and proficiency in reading and writing Hebrew. Exclusion Criteria: 1. Heavy vaginal bleeding or diagnosis of incomplete abortion. 2. Signs of infection and/or suspicion of septic abortion 3. Known uterine anomalies- including septate, bicornuate, unicornuate, or didelphys uterus. 4. Prior medical or surgical treatment during the current pregnancy 5. History of intrauterine adhesions 6. History of ≥ 3 prior miscarriages. 7. History of ≥ 3 prior cesarean sections. 8. History of myomectomy via abdominal or hysteroscopic approach.
Where it's running
-
Shamir Medical Center
Be’er Ya‘aqov, Israel Recruiting -
Sheba Medical Center, Tel Hashomer
Ramat Gan, Israel Active not recruiting
Study contacts
- Principal investigator: Noam Smorgick, MD — Assaf-Harofeh Medical Center
- Study coordinator: Noam Smorgick, MD
- Email: gyn-endo@shamir.gov.il
- Phone: +972-8-9779000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.