Studying heart metabolism using MRI techniques
In Vivo Cardiac Metabolism in Normal, Ischemic, and Cardiomyopathic Patients During Rest and Stress
This study is testing if using MRI to look at heart metabolism can help us understand how energy issues in the heart might lead to heart failure in both healthy people and those with heart conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Trial ID | NCT00181259 on ClinicalTrials.gov |
What this trial studies
This observational study utilizes magnetic resonance spectroscopy to investigate the metabolism of cardiac muscle in both healthy individuals and patients with various heart conditions, including left ventricular hypertrophy, dilated cardiomyopathy, and coronary artery disease. The goal is to determine if reduced energy metabolism contributes to heart failure and impaired heart function. By measuring heart metabolism non-invasively, the study aims to provide insights into the underlying mechanisms of heart failure without the need for blood sampling or tissue biopsies.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with either heart failure, left ventricular hypertrophy, coronary artery disease, or healthy individuals without a history of heart disease.
Not a fit: Patients with contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of heart metabolism in heart failure, potentially leading to improved treatment strategies.
How similar studies have performed: Other studies using magnetic resonance spectroscopy have shown promise in understanding cardiac metabolism, suggesting this approach is both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age \> 18 years * Healthy subjects: no history of heart disease * Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40% * Left ventricular hypertrophy: wall thickness \>1.2cm * Coronary artery disease: \>50% coronary lesion or positive stress test Exclusion Criteria: * contraindication to MRI
Where this trial is running
Baltimore, Maryland
- Johns Hopkins Medical Institutions — Baltimore, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Robert G. Weiss, MD — Johns Hopkins University
- Study coordinator: Robert G. Weiss, MD
- Email: rweiss@jhmi.edu
- Phone: 410-955-1703
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.