Study of Children With Acute Food Protein Induced Enterocolitis Syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to collect clinical features and allergy testing data from children diagnosed with acute Food Protein Induced Enterocolitis Syndrome (FPIES) over a three-year period. FPIES is a non-IgE mediated food allergy that can lead to severe gastrointestinal symptoms, often misdiagnosed due to its rarity and the lack of awareness among clinicians. The study will utilize established diagnostic criteria to ensure accurate identification of affected children and monitor their condition over time. The findings will help to better understand the evolution and atypical presentations of FPIES in the pediatric population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age from 0 to 17 years old,
* seen in allergologist visit for acute FPIES, due to history of suggestive clinical symptoms, confirmed by the criteria published in 2017 in the JACI (Nowak-Wegrzyn et al, JACI 2017), or by an oral food challenge for diagnosis in the absence of the requested clinical criteria,
* affiliated to social security (public healthcare system)
* signed consent of one of the parents or the holder of parental authority

Exclusion Criteria:

* Associated pathology that may contraindicate OFC at the discretion of the investigating physician. In particular justifying permanent treatment with a beta-blocker or an angiotensin-converting enzyme inhibitor.

Where it's running

• Chu Angers
  Angers, France Recruiting
• Chi Robert Ballanger
  Aulnay-sous-Bois, France Recruiting
• Chu Clermont-Ferrand
  Clermont-Ferrand, France Recruiting
• Hopital Civils de Colmar
  Colmar, France Recruiting
• Ch Haguenau
  Haguenau, France Recruiting
• Chr Lille Hopital Jeanne de Flandre
  Lille, France Recruiting

Study contacts

• Study coordinator: Sibylle BLANC, MD
• Email: blanc.si@pediatrie-chulenval-nice.fr
• Phone: 0492030841

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Finding the best way to diagnose food protein-induced enterocolitis syndrome

  This study is testing a new way to diagnose food protein-induced enterocolitis syndrome (FPIES) in people aged 1-60 by giving them small amounts of food to see how they react.

  Recruiting at 2 sites NYU Langone Health · New York, New York and 1 other locations · NCT06683521

• Understanding Non-IgE-mediated Food Allergies in Children

  This study is trying to learn more about non-IgE-mediated food allergies in children, like certain gastrointestinal issues, to help improve how these allergies are understood and managed.

  Recruiting Federico II University · Naples · NCT04462978

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.