Striatal temporal interference stimulation to improve sentence understanding in mild cognitive impairment
Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases
NA · Masaryk University · NCT07449117
This project will try a 20-minute non-invasive brain stimulation called temporal interference aimed at the striatum to see if it helps people with amnestic MCI, Parkinson's disease with MCI, or Lewy body MCI understand sentences better and alters brain connectivity.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Masaryk University (other) |
| Locations | 1 site (Brno, South Moravian) |
| Trial ID | NCT07449117 on ClinicalTrials.gov |
What this trial studies
This randomized crossover study delivers a single session of active temporal interference stimulation (TIS) targeting deep striatal/fronto-striatal structures and a separate sham session, with order randomized. Each stimulation session lasts about 20 minutes while participants perform a sentence comprehension task. Resting-state fMRI is collected before and after stimulation to measure immediate offline effects on brain connectivity and potential neuroplastic changes. The study focuses on patients with neurodegenerative conditions who commonly have sentence comprehension and communication difficulties.
Who should consider this trial
Good fit: Adults diagnosed with amnestic MCI, Parkinson's disease with MCI, or possible/probable MCI with Lewy bodies who can undergo MRI, tolerate non-invasive brain stimulation, and complete a sentence comprehension task are ideal candidates.
Not a fit: People with severe psychiatric illness, other major neurological disorders, severe head trauma, uncompensated medical/oncological disease, or MRI-incompatible implants (for example pacemakers) are excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, this non-invasive approach could offer a way to improve sentence comprehension and modulate language-related brain circuits in people with mild cognitive impairment.
How similar studies have performed: Related non-invasive methods (tDCS/TMS) have shown mixed, modest effects on language and cognition, while temporal interference stimulation targeting deep structures is a newer approach with limited human data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI). Exclusion Criteria: * Any severe psychiatric disorder. * History of other neurological diseases affecting the central nervous system. * Severe head trauma. * Uncompensated internal or oncological disease. * Presence of MRI-incompatible metal in the body (e.g., pacemaker).
Where this trial is running
Brno, South Moravian
- CEITEC MU (Central European Institute of Technology, Masaryk University) — Brno, South Moravian, Czechia (RECRUITING)
Study contacts
- Study coordinator: Ľubomíra Nováková, Ph.D.
- Email: lubomira.novakova@ceitec.muni.cz
- Phone: +420 549 497 766
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mild Cognitive Impairment Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment, Temporal Interference Stimulation, Functional Magnetic Resonance Imaging, Sentence Comprehension, Language Processing, Brain Connectivity