Striatal temporal interference stimulation to improve sentence understanding in mild cognitive impairment
Official title: Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases
Run by Masaryk University · NCT07449117 · Data updated 2026-11-12
This project will try a 20-minute non-invasive brain stimulation called temporal interference aimed at the striatum to see if it helps people with amnestic MCI, Parkinson's disease with MCI, or Lewy body MCI understand sentences better and alters brain connectivity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years to 80 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Masaryk University Academic / other |
| Locations | 1 site (Brno, South Moravian) |
| Status | Recruiting |
| Started | March 2026 |
| Main results expected | December 2027 |
| Study ends | December 2028 |
| Registry record updated | March 4, 2026 |
| Trial ID | NCT07449117 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults diagnosed with amnestic MCI, Parkinson's disease with MCI, or possible/probable MCI with Lewy bodies who can undergo MRI, tolerate non-invasive brain stimulation, and complete a sentence comprehension task are ideal candidates.
✕Probably not a fit
People with severe psychiatric illness, other major neurological disorders, severe head trauma, uncompensated medical/oncological disease, or MRI-incompatible implants (for example pacemakers) are excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized crossover study delivers a single session of active temporal interference stimulation (TIS) targeting deep striatal/fronto-striatal structures and a separate sham session, with order randomized. Each stimulation session lasts about 20 minutes while participants perform a sentence comprehension task. Resting-state fMRI is collected before and after stimulation to measure immediate offline effects on brain connectivity and potential neuroplastic changes. The study focuses on patients with neurodegenerative conditions who commonly have sentence comprehension and communication difficulties.
Why it matters
Potential benefit: If successful, this non-invasive approach could offer a way to improve sentence comprehension and modulate language-related brain circuits in people with mild cognitive impairment.
How similar studies have gone: Related non-invasive methods (tDCS/TMS) have shown mixed, modest effects on language and cognition, while temporal interference stimulation targeting deep structures is a newer approach with limited human data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI). Exclusion Criteria: * Any severe psychiatric disorder. * History of other neurological diseases affecting the central nervous system. * Severe head trauma. * Uncompensated internal or oncological disease. * Presence of MRI-incompatible metal in the body (e.g., pacemaker).
Where it's running
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CEITEC MU (Central European Institute of Technology, Masaryk University)
Brno, South Moravian, Czechia Recruiting
Study contacts
- Study coordinator: Ľubomíra Nováková, Ph.D.
- Email: lubomira.novakova@ceitec.muni.cz
- Phone: +420 549 497 766
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.