Strengthening muscles to help with moderate obstructive sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with moderate obstructive sleep apnea hypopnea syndrome (OSAS) who have few or no symptoms and no cardiovascular comorbidities. It aims to evaluate the effectiveness of a rehabilitation program that strengthens the inspiratory and oropharyngeal muscles to alleviate airway obstruction during sleep. The intervention involves specific muscle training exercises designed to improve muscle tone and function. The study will assess the outcomes of this approach in improving sleep quality and reducing apnea events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Moderate SAHOS (15 ≤ AHI ≤30);
* Body Mass Index (BMI) \< 35 ;
* Patient affiliated or entitled to a social security scheme;
* Patient having signed a consent to participate in the study.

Exclusion Criteria:

* Excessive daytime sleepiness: Epworth sleepiness score \> 10 ;
* Professional driving and history of accidents related to sleepiness;
* Severe obstructive or restrictive ventilatory disorders of neuromuscular origin authenticated by respiratory function tests;
* Patients undergoing treatment for OSAS or requiring immediate initiation of continuous positive airway pressure (CPAP) or a mandibular advancement orthosis;
* Patients who have stopped CPAP or orthosis treatment in less than one month;
* Patients undergoing cardiorespiratory exercise rehabilitation or starting regular physical training;
* Uncompensated heart failure, thoracic sternotomy surgery \< 4 months;
* Marked osteoporosis with history of rib fractures;
* History of spontaneous pneumothorax;
* Severe asthma;
* Perforated eardrum or any other ear condition;
* Pulmonary hypertension;
* History of pharyngeal surgery to treat sleep apnea;
* Pregnant women or women in labor;
* Individuals deprived of their liberty or hospitalized without consent;
* Adults subject to legal protective measures (guardianship or conservatorship).

Contraindications for MRI

* Patient with claustrophobia;
* Patient for whom MRI is contraindicated (pacemaker, metallic heart valve, metallic foreign body in the eye).

Where it's running

• Centre Hospitalier Universitaire
  Saint-Etienne, France Recruiting
• CHU de Grenoble
  Grenoble, France Not yet recruiting

Study contacts

• Principal investigator: Amandine Zellag — Centre Hospitalier Universitaire de Saint Etienne
• Study coordinator: Amandine ZELLAG, physiotherapist
• Email: amandine.zellag@chu-st-etienne.fr
• Phone: (0)4 77 12 73 93

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.