Strategies to reduce muscle loss in aging women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the impact of aging on muscle mass and function, particularly focusing on the differences between men and women. It aims to understand how menopause affects muscle loss and physical disability in women aged 18-65 who do not regularly engage in resistance exercise. The study will explore the relationship between body composition changes, such as increased fat infiltration into muscle, and the development of sarcopenia. By identifying sex-specific strategies, the research seeks to mitigate the effects of sarcopenia and improve health outcomes for aging populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Biological woman, 18-65 years of age
* Body mass index (BMI) 18-30 kg/m2
* Non smoker
* Not performing regular resistance type exercise
* Participant is willing and able to give informed consent for participation in the study

Exclusion Criteria:

* A BMI \<18 or \>39 kg·m-2
* Active cardiovascular disease: uncontrolled hypertension (Blood pressure \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event.
* Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
* Respiratory disease including pulmonary hypertension or Chronic obstructive pulmonary disease (COPD).
* Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), polycystic ovarian syndrome (PCOS), inborn/ congenital errors of metabolism (e.g. Phenylketonuria (PKU), galactosaemia)
* Active inflammatory bowel disease.
* Acute infection.
* Acute or chronic renal disease.
* Malignancy (or history of malignancy with 5 y).
* Recent (within 6 mo) or current steroid treatment, hormone replacement therapy (HRT), hormonal contraception, or other hormonal therapies that may interfere with outcome measures.
* Coagulopathy.
* Musculoskeletal or neurological disorders.
* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance.
* Amenorrhoea for a reason other than menopause.
* Contraindications for Magnetic Resonance Imaging (MRI).
* Allergy or sensitivity to local anaesthesia, or dressing adhesive.
* Inner ear pathology or vertigo

Where it's running

• Queens Medical Centre Campus
  Nottingham, United Kingdom Recruiting

Study contacts

• Study coordinator: Matthew Brook
• Email: Matthew.Brook@nottingham.ac.uk
• Phone: 0115 8230248

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.