Strategies to prevent weight regain after stopping GLP-1 medications
Identifying Strategies to Curtail Weight Regain After GLP-1 Receptor Agonist Treatment Cessation
This study is testing different ways to help people keep off weight they lost while on GLP-1 medications after they stop taking them.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT06273163 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of different interventions to help maintain weight loss after patients discontinue GLP-1 receptor agonist medications. Participants who have lost more than 10% of their body weight while on GLP-1s will be randomly assigned to receive either medically tailored meals, a subscription to the Noom® app, or standard lifestyle counseling. The trial will last four months and will assess treatment adherence and satisfaction among the different groups. The goal is to identify sustainable strategies for weight maintenance that could be more cost-effective than long-term medication use.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have lost more than 10% of their body weight while on GLP-1 receptor agonists and have stopped treatment within the last 30 days.
Not a fit: Patients with major psychiatric illnesses, substance misuse issues, or medical conditions that prevent them from participating in the dietary interventions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide patients with effective strategies to maintain weight loss without the need for continuous medication.
How similar studies have performed: Other studies have explored weight maintenance strategies after weight loss, but this specific approach combining meal replacements and a mobile app is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * 18 years of age or older; * ability to read, write, and speak English; * ability to provide informed consent; * greater than 10% GLP-1 Receptor Agonist induced weight loss * less than 30-days since GLP-1 Receptor Agonist cessation; * willing to participate. Exclusion criteria: * major psychiatric illness or substance misuse that could impair ability to participate; * presence of a medical condition or dietary restriction precluding eating study meals or weight loss (e.g., medical condition requiring liquid diet, pregnancy, eating disorder); * participation in a study or program involving medically tailored meals or Noom® within the past 12-months.
Where this trial is running
Dallas, Texas
- UT Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Kelseanna Hollis-Hansen, PhD, MPH — UT Southwestern Medical Center
- Study coordinator: Carolyn Haskins, MS
- Email: niche@utsouthwestern.edu
- Phone: (469) 431-3992
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.