Stopping antibiotics early in older adults hospitalized with a viral lung infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Older adults hospitalized with signs of lower respiratory infection will have microbiological sampling within 48 hours and multiplex PCR testing to identify viral pathogens. When a viral infection is identified and there is no evidence of bacterial co-infection, the protocol calls for early discontinuation of antibiotics; patients will then be followed for clinical outcomes, complications, and need to restart antibiotics. The intervention is being implemented at university hospitals in France and compared with usual antibiotic management pathways. The goal is to measure safety, clinical recovery, and antibiotic exposure in this higher-risk, comorbid population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients ≥ 65 years affiliated to a social security scheme
* Hospitalized for a lower respiratory infection defined as:

  * the presence of 2 of the following 4 signs:
  * hyperthermia \>38°C,
  * hyperleukocytosis ≥12000 or ≤4000,
  * purulent aspirations/sputum,
  * rales on pulmonary auscultation indicating parenchymal damage
  * associated with a pulmonary image (standard X-ray, CT scan or ultrasound)
* Microbiological diagnostic sample taken within 48 hours
* Informed consent of the patient or their representative

Exclusion Criteria:

* Hospitalization planned for \< 48 hours or transfer planned to another center within 7 days

  * Patient in septic shock,
  * Febrile aplasia
  * Absence of diagnostic microbiological sampling (\> 48 hours after admission)
  * Moribund patient,
  * Death expected within the week
  * Inhalation proven by endoscopy or eyewitness
  * Purulent pleurisy, lung abscess, or other concomitant bacterial infection requiring antibiotic therapy.

Where it's running

• CHRU Amiens
  Amiens, France Recruiting

Study contacts

• Study coordinator: Jean-Philippe LANOIX, Pr
• Email: lanoix.jean-philippe@chu-amiens.fr
• Phone: 33+32668813

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.