Steps to Improve Walking and Reduce Falls in Parkinson's — Tel Aviv & Bologna

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, site-specific trial applies speed-dependent treadmill training (SDTT) with and without mechanically and VR-triggered gait perturbations to people with Parkinson's disease (Hoehn & Yahr I–III). Participants undergo lab-based kinematic, EMG, and EEG measurements before and after training and are monitored for transfer of improvements to daily-life gait using wearable sensors. The protocol is one of three parallel randomized trials using a shared core design with pooled analysis across sites to examine neural and biomechanical mechanisms and individual response differences. Outcomes include lab gait measures, neural activity changes, gait self-efficacy, and mobility in daily life.

Why it matters

Who can join: the full rules

Inclusion criteria

1. Diagnosis of PD according to the MDS Criteria
2. Hoehn and Yahr stages I to III;
3. Movement Disorder Society-sponsored version of the Unified Parkinson Disease Rating Scale (MDS-UPDRS) gait sub-score of 1 or more
4. Signed informed consent to participation

Exclusion criteria

* Any known general health condition likely to interfere with or to pose a contraindication to non-medically supervised physical exercise.
* Moderate or severe depression (BDI-II ≥18)
* Cognitive impairment which may preclude the possibility to provide a fully informed consent to enrolment.
* Linguistic comprehension capacity less than 75% in ordinary conversation
* Severe psychiatric comorbidity which may interfere with compliance to the study protocol History of or current status of substance dependency
* Unable to walk less than 1 floor
* Thoracic pain in the last 4 weeks
* Currently enrolled in other interventional studies
* Implanted Deep Brain Stimulation device

Where it's running

• Tel-Aviv Sourasky Medical Center
  Tel Aviv, Israel Recruiting
• IRCCS Istituto delle Scienze Neurologiche di Bologna
  Bologna, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.