Stepping-based cognitive-motor training to improve walking and thinking in Parkinson disease
Cognitive-motor Training on Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson Disease
NA · National Yang Ming Chiao Tung University · NCT06588439
This project will test whether stepping-based cognitive-motor training can improve walking, executive thinking, and brain activity in people with Parkinson disease.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 40 Years to 80 Years |
| Sex | All |
| Sponsor | National Yang Ming Chiao Tung University (other) |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06588439 on ClinicalTrials.gov |
What this trial studies
This interventional study compares a stepping-based cognitive-motor training program with conventional physiotherapy in people with idiopathic Parkinson disease. Participants who meet eligibility will receive repeated sessions of either combined cognitive-plus-stepping exercises or standard physiotherapy, with outcomes measured before and after the intervention. Primary outcomes include walking ability and executive function, and brain activity changes will be monitored using electroencephalography (EEG). The trial is conducted at National Yang Ming Chiao Tung University in Taipei and enrolls ambulatory participants on stable dopaminergic medication.
Who should consider this trial
Good fit: Ideal candidates are people with idiopathic Parkinson disease who can walk 10 meters without an aid, have been on stable dopaminergic medication for at least 2 weeks, have a Mini-Mental Status Examination score of 24 or higher, and have at least a junior high education.
Not a fit: Patients with other neurological, musculoskeletal, or cardiopulmonary disorders, a history of brain surgery (such as deep brain stimulation), severe cognitive impairment, or who cannot walk independently are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the program could improve mobility, higher-order thinking (executive function), and related brain activity, potentially reducing falls and improving daily function.
How similar studies have performed: Stepping-based cognitive-motor training has shown improvements in cognition, balance, and gait in older adults, but evidence specifically in Parkinson disease is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnoses of idiopathic Parkinson disease * Stable dopaminergic medicine ≥ 2 weeks * Able to walk 10 meters without aid * Mini-Mental Status Examination ≥ 24 points * No uncorrected visual or auditory disorders * Education at least junior high school * No other disease may affect balance Exclusion Criteria: * Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders * History of brain surgery (e.g. deep brain stimulation)
Where this trial is running
Taipei
- National Yang Ming Chiao Tung University — Taipei, Taiwan (RECRUITING)
Study contacts
- Study coordinator: Yea-Ru Yang, PhD
- Email: yryang@nycu.edu.tw
- Phone: +886228267279
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Parkinson Disease, Cognitive-motor training, Executive function, Gait, Electroencephalography