Stepping-based cognitive-motor training to improve walking and thinking in Parkinson disease
Official title: Cognitive-motor Training on Brain Activity, Cognitive Function, and Walking Ability in People With Parkinson Disease
Run by National Yang Ming Chiao Tung University · NCT06588439 · Data updated 2026-11-12
This project will test whether stepping-based cognitive-motor training can improve walking, executive thinking, and brain activity in people with Parkinson disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 80 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | National Yang Ming Chiao Tung University Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | March 15, 2025 |
| Main results expected | August 31, 2027 |
| Study ends | August 31, 2027 |
| Registry record updated | June 12, 2025 |
| Trial ID | NCT06588439 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with idiopathic Parkinson disease who can walk 10 meters without an aid, have been on stable dopaminergic medication for at least 2 weeks, have a Mini-Mental Status Examination score of 24 or higher, and have at least a junior high education.
✕Probably not a fit
Patients with other neurological, musculoskeletal, or cardiopulmonary disorders, a history of brain surgery (such as deep brain stimulation), severe cognitive impairment, or who cannot walk independently are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares a stepping-based cognitive-motor training program with conventional physiotherapy in people with idiopathic Parkinson disease. Participants who meet eligibility will receive repeated sessions of either combined cognitive-plus-stepping exercises or standard physiotherapy, with outcomes measured before and after the intervention. Primary outcomes include walking ability and executive function, and brain activity changes will be monitored using electroencephalography (EEG). The trial is conducted at National Yang Ming Chiao Tung University in Taipei and enrolls ambulatory participants on stable dopaminergic medication.
Why it matters
Potential benefit: If successful, the program could improve mobility, higher-order thinking (executive function), and related brain activity, potentially reducing falls and improving daily function.
How similar studies have gone: Stepping-based cognitive-motor training has shown improvements in cognition, balance, and gait in older adults, but evidence specifically in Parkinson disease is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnoses of idiopathic Parkinson disease * Stable dopaminergic medicine ≥ 2 weeks * Able to walk 10 meters without aid * Mini-Mental Status Examination ≥ 24 points * No uncorrected visual or auditory disorders * Education at least junior high school * No other disease may affect balance Exclusion Criteria: * Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders * History of brain surgery (e.g. deep brain stimulation)
Where it's running
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National Yang Ming Chiao Tung University
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Yea-Ru Yang, PhD
- Email: yryang@nycu.edu.tw
- Phone: +886228267279
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.