Sputum-guided treatment and care management for COPD
Official title: Sputum-guided Treatment With Comprehensive Care Management for Respiratory Improvement to Provide Value and Escalate Care - A Randomized-controlled Trial
Run by McMaster University · NCT04890938 · Data updated 2026-11-12
This study tests a new approach for people with COPD that uses sputum tests to guide treatment and offers personalized care to help reduce flare-ups and hospital visits.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 128 (estimated) |
| Sponsor | McMaster University Academic / other |
| Locations | 2 sites (Hamilton, Ontario and 1 other locations) |
| Status | Recruiting |
| Started | May 27, 2022 |
| Main results expected | March 2025 |
| Study ends | August 2025 |
| Registry record updated | November 21, 2024 |
| Trial ID | NCT04890938 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are COPD patients with at least two exacerbations in the past year and a history of smoking.
✕Probably not a fit
Patients with severe mental illness not controlled by medication or a life expectancy of less than six months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates a two-pronged intervention for patients with chronic obstructive pulmonary disease (COPD) who experience frequent flare-ups. It combines sputum biomarker-directed treatment of airway inflammation with comprehensive care management over a six-month period. Participants will receive personalized care that includes case management, self-management education, and coordination of resources, alongside regular clinic visits to monitor their condition. The aim is to reduce hospital readmissions and improve overall management of COPD.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the frequency of COPD flare-ups and hospital readmissions for patients.
How similar studies have gone: Other studies have shown promise with similar comprehensive care management approaches, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>=2 exacerbations of COPD in the last 12-months, FEV1/FVC\<0.7 or radiologic emphysema, with a \>-10 pack-year smoking history Exclusion Criteria: * severe mental illness not controlled by medication or life-expectancy less than 6-months
Where it's running
-
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada Recruiting -
Hamilton General Hospital
Hamilton, Ontario, Canada Not yet recruiting
Study contacts
- Principal investigator: Terence Ho, MB, MSc — St. Joseph's Healthcare Hamilton
- Study coordinator: Terence N Ho, MB, MSc
- Email: hot4@mcmaster.ca
- Phone: 9055221155
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.