Spinal or general anesthesia for inflammation after kidney stone removal (PCNL)
Comparison of Spinal and General Anesthesia on Systemic Inflammatory Response in Patients Undergoing Percutaneous Nephrolithotomy: Evaluation of SII, SIRI, AISI, NLR, and RDW
This study will see if spinal or general anesthesia causes less inflammation in adults having percutaneous nephrolithotomy (PCNL).
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Elazıg Fethi Sekin Sehir Hastanesi Academic / other |
| Locations | 1 site (Elâzığ, Elaziğ) |
| Trial ID | NCT07326670 on ClinicalTrials.gov |
What this trial studies
This observational study compares perioperative changes in routine blood-based inflammatory markers between patients who receive spinal anesthesia and those who receive general anesthesia for percutaneous nephrolithotomy (PCNL). Preoperative and postoperative complete blood count values will be used to calculate indices such as SII, SIRI, AISI, NLR, and RDW, and these will be compared alongside clinical outcomes. Adult patients (ASA I–III) treated at a single center in Elâzığ, Turkey are eligible, while patients with active infection, malignancy, chronic inflammatory disease, immunosuppression, pregnancy, or ASA IV–V are excluded. Anesthesia is not assigned by the study; routine clinical care determines the approach and investigators analyze the resulting data.
Who should consider this trial
Good fit: Adults aged 18 and older undergoing PCNL who are ASA physical status I–III and who do not have active infection, cancer, chronic inflammatory disease, pregnancy, or use immunosuppressive therapy.
Not a fit: Patients who are ASA IV–V, children under 18, pregnant individuals, or those with active infection, malignancy, chronic inflammatory conditions, or on immunosuppressive medications are unlikely to be eligible or to benefit from the findings.
Why it matters
Potential benefit: If successful, the findings could help clinicians choose the type of anesthesia that minimizes postoperative inflammation and related complications after PCNL.
How similar studies have performed: Prior studies in other surgical settings have sometimes found differences in inflammatory markers between spinal and general anesthesia, but evidence specifically for PCNL is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status class I-III * Patients aged 18 years and older Exclusion Criteria: * American Society of Anesthesiologists (ASA) physical status class IV or V * Patients younger than 18 years * Active infection or diagnosis of sepsis * Malignancy * Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) * Use of immunosuppressive therapy * Pregnancy
Where this trial is running
Elâzığ, Elaziğ
- Fethi Sekin City Hospital — Elâzığ, Elaziğ, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Sevim ŞENOL KARATAŞ, MD
- Email: drsevimkaratas@gmail.com
- Phone: +905325736611
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.