Spinal fluid immunoglobulin free light chains to predict multiple sclerosis course

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure cerebrospinal fluid (CSF) immunoglobulin free light chains (FLC) in adults diagnosed with multiple sclerosis by the 2017 McDonald criteria or with optic neuritis who are undergoing lumbar puncture and brain MRI as part of routine care. FLC levels will be compared with oligoclonal band status and correlated with clinical outcomes including conversion from clinically isolated syndrome to definite MS and disability measured by the Expanded Disability Status Scale (EDSS). The protocol uses quantitative FLC assays to address reproducibility and dynamic range limitations of OCB testing. Routine clinical follow-up and imaging data will be used to determine whether baseline CSF FLC predicts longer-term disease course.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 at the time of enrollment
* Diagnosis of multiple sclerosis according to 2017 McDonald diagnostic criteria or optic neuritis (fulfilling or not criteria for multiple sclerosis, i.e. clinically isolated syndrome)
* Receiving both lumbar puncture and brain MRI for the routine diagnostic work-up

Exclusion Criteria:

• None

Where it's running

• CHU Brugmann
  Brussels, Belgium Recruiting

Study contacts

• Principal investigator: Serena Borrelli — CHU Brugmann
• Study coordinator: Serena Borrelli, MD
• Email: Serena.BORRELLI@chu-brugmann.be
• Phone: 3224750308

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.