Clinical trial Recruiting at 1 site Observational Ages 60 and up

SPICE: Community-based pathway to screen and prevent declines in older adults' physical and mental abilities in Singapore

Official title: Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore

Run by National University Hospital, Singapore · NCT07525583 · Data updated 2026-11-12

This program tries a digital, community screening and targeted support pathway to prevent declines in physical and mental abilities for adults aged 60 and older in Singapore.

Quick facts

Study typeObservational
Ages60 Years and up
SexAll
Enrollment2500 (estimated)
SponsorNational University Hospital, Singapore
Academic / other
Locations1 site (Singapore)
StatusRecruiting
StartedApril 1, 2025
Main results expectedMay 30, 2027
Study endsSeptember 30, 2027
Registry record updatedApril 13, 2026
Trial IDNCT07525583 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 60 years or older who are robust or pre-frail, able to give consent and follow instructions, are the intended participants.

Probably not a fit

People who are already frail or have a terminal illness were excluded and are unlikely to benefit from this prevention-focused pathway.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The SPICE pathway uses WHO ICOPE digital screening tools in community venues to identify early declines across mobility, cognition, nutrition, psychological, and sensory domains. Participants who screen positive receive structured in-depth assessments, traffic-light risk stratification, and personalized care plans linking community interventions or medical referral as needed. The intervention package emphasizes multidomain supports such as exercise, nutrition, cognitive stimulation, and social engagement delivered through a hub-and-spoke model anchored by regional health services. Longitudinal follow-up will track feasibility, uptake, functional trajectories, adherence, and cost-effectiveness of the implementation.

Why it matters

Potential benefit: If successful, this could help older adults maintain function and delay progression to frailty by detecting early decline and providing targeted support.

How similar studies have gone: Similar ICOPE-based and multidomain prevention programs have shown promising results in pilot implementations, though large-scale long-term evidence is still limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* pre-frail or robust older adults who can provide consent and follow instructions

Exclusion Criteria:

* frail or with terminal illness

Where it's running

  • National University Hospital
    Singapore, Singapore
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.