SPICE: Community-based pathway to screen and prevent declines in older adults' physical and mental abilities in Singapore
Official title: Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in Elders (SPICE) Through Multisectoral Collaboration in Singapore
Run by National University Hospital, Singapore · NCT07525583 · Data updated 2026-11-12
This program tries a digital, community screening and targeted support pathway to prevent declines in physical and mental abilities for adults aged 60 and older in Singapore.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | National University Hospital, Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | May 30, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07525583 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 60 years or older who are robust or pre-frail, able to give consent and follow instructions, are the intended participants.
✕Probably not a fit
People who are already frail or have a terminal illness were excluded and are unlikely to benefit from this prevention-focused pathway.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The SPICE pathway uses WHO ICOPE digital screening tools in community venues to identify early declines across mobility, cognition, nutrition, psychological, and sensory domains. Participants who screen positive receive structured in-depth assessments, traffic-light risk stratification, and personalized care plans linking community interventions or medical referral as needed. The intervention package emphasizes multidomain supports such as exercise, nutrition, cognitive stimulation, and social engagement delivered through a hub-and-spoke model anchored by regional health services. Longitudinal follow-up will track feasibility, uptake, functional trajectories, adherence, and cost-effectiveness of the implementation.
Why it matters
Potential benefit: If successful, this could help older adults maintain function and delay progression to frailty by detecting early decline and providing targeted support.
How similar studies have gone: Similar ICOPE-based and multidomain prevention programs have shown promising results in pilot implementations, though large-scale long-term evidence is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * pre-frail or robust older adults who can provide consent and follow instructions Exclusion Criteria: * frail or with terminal illness
Where it's running
-
National University Hospital
Singapore, Singapore Recruiting
Study contacts
- Study coordinator: Reshma Merchant (Associate Professor), MBChB (Edin)
- Email: mdcram@nus.edu.sg
- Phone: +6567724368
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.