Speckle-tracking heart ultrasound to help predict failure when coming off a ventilator
Official title: Combined Thoracic Ultrasound Using Speckle Tracking for the Prediction of Weaning Failure : a Prospective Multicenter Study
Run by Assistance Publique Hopitaux De Marseille · NCT03657524 · Data updated 2026-11-12
This study will test whether speckle-tracking echocardiography performed during a weaning trial can help predict which mechanically ventilated ICU patients will fail to breathe on their own.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 110 (estimated) |
| Sponsor | Assistance Publique Hopitaux De Marseille Academic / other |
| Locations | 1 site (Marseille) |
| Status | Recruiting |
| Started | May 20, 2019 |
| Main results expected | May 21, 2026 |
| Study ends | May 21, 2026 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT03657524 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults in the ICU on mechanical ventilation who meet criteria for a weaning (spontaneous breathing) trial, are in sinus rhythm, and have adequate echocardiographic windows are ideal candidates.
✕Probably not a fit
Patients with non-sinus cardiac rhythms, tracheotomy, neuromuscular disorders, pregnancy, or poor echogenicity are unlikely to benefit or be eligible for the test.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Deciding when to remove a breathing tube is difficult because current weaning predictors are imperfect. This interventional diagnostic study will perform speckle-tracking echocardiography during a standardized weaning trial to measure cardiac deformation parameters that may indicate diastolic dysfunction and elevated filling pressures. Investigators will compare the diagnostic accuracy of speckle-tracking with conventional echocardiography and lung ultrasound for predicting weaning failure. The trial enrolls adult ICU patients ready for a spontaneous breathing trial and excludes patients with arrhythmia, tracheotomy, neuromuscular disease, pregnancy, or inadequate echocardiographic windows.
Why it matters
Potential benefit: If successful, the approach could give clinicians a more reliable tool to predict extubation failure, potentially reducing emergency reintubations and ICU complications.
How similar studies have gone: Conventional echocardiography combined with lung ultrasound has shown promising results for predicting post-extubation distress, but using speckle-tracking specifically for this purpose is novel and has not been previously studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial. Exclusion Criteria: * Less than 18 years old. * Pregnancy * Non sinusal cardiac rhythm * Neuro Myopathy * Tracheotomy * Lack of echogenicity to perform at least a four chamber apical view
Where it's running
-
Assistance Publique Hôpitaux de Marseille
Marseille, France Recruiting
Study contacts
- Study coordinator: Laurent ZIELESKIEWICZ
- Email: laurent.zieleskiewicz@ap-hm.fr
- Phone: 04 91 96 53 77
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Bedside heart ultrasound to predict successful removal of the breathing tube in ICU patients
This project will test whether bedside heart ultrasound measurements can predict successful extubation in adults on mechanical ventilation in the ICU.
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Right-heart ultrasound to predict success of removing the breathing tube in ICU patients
This study will try to see if bedside right-ventricle ultrasound measurements (like TAPSE) can predict whether adult ICU patients on mechanical ventilation will stay off the breathing tube after extubation.
-
Evaluating Heart Function During Breathing Trials in ICU Patients
This study tests which type of breathing trial is easiest on the heart for ICU patients who are trying to breathe on their own without help from machines.
-
Understanding factors related to weaning failure in critically ill patients on mechanical ventilation
This study looks at why some critically ill patients on mechanical ventilation have trouble being taken off the ventilator, especially during their ICU stay.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.