Speckle-tracking heart ultrasound to help predict failure when coming off a ventilator
Combined Thoracic Ultrasound Using Speckle Tracking for the Prediction of Weaning Failure : a Prospective Multicenter Study
NA · Assistance Publique Hopitaux De Marseille · NCT03657524
This study will test whether speckle-tracking echocardiography performed during a weaning trial can help predict which mechanically ventilated ICU patients will fail to breathe on their own.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique Hopitaux De Marseille (other) |
| Locations | 1 site (Marseille) |
| Trial ID | NCT03657524 on ClinicalTrials.gov |
What this trial studies
Deciding when to remove a breathing tube is difficult because current weaning predictors are imperfect. This interventional diagnostic study will perform speckle-tracking echocardiography during a standardized weaning trial to measure cardiac deformation parameters that may indicate diastolic dysfunction and elevated filling pressures. Investigators will compare the diagnostic accuracy of speckle-tracking with conventional echocardiography and lung ultrasound for predicting weaning failure. The trial enrolls adult ICU patients ready for a spontaneous breathing trial and excludes patients with arrhythmia, tracheotomy, neuromuscular disease, pregnancy, or inadequate echocardiographic windows.
Who should consider this trial
Good fit: Adults in the ICU on mechanical ventilation who meet criteria for a weaning (spontaneous breathing) trial, are in sinus rhythm, and have adequate echocardiographic windows are ideal candidates.
Not a fit: Patients with non-sinus cardiac rhythms, tracheotomy, neuromuscular disorders, pregnancy, or poor echogenicity are unlikely to benefit or be eligible for the test.
Why it matters
Potential benefit: If successful, the approach could give clinicians a more reliable tool to predict extubation failure, potentially reducing emergency reintubations and ICU complications.
How similar studies have performed: Conventional echocardiography combined with lung ultrasound has shown promising results for predicting post-extubation distress, but using speckle-tracking specifically for this purpose is novel and has not been previously studied.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial. Exclusion Criteria: * Less than 18 years old. * Pregnancy * Non sinusal cardiac rhythm * Neuro Myopathy * Tracheotomy * Lack of echogenicity to perform at least a four chamber apical view
Where this trial is running
Marseille
- Assistance Publique Hôpitaux de Marseille — Marseille, France (RECRUITING)
Study contacts
- Study coordinator: Laurent ZIELESKIEWICZ
- Email: laurent.zieleskiewicz@ap-hm.fr
- Phone: 04 91 96 53 77
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Weaning Failure of Mechanical Ventilation