Specific walking patterns in people living with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project at CHU Lille will compare walking patterns between adults with multiple sclerosis and healthy volunteers. Participants (ages 18–65) with a confirmed MS diagnosis according to McDonald 2017 and EDSS of 6 or lower who have been on stable treatment for at least two months will complete standardized gait evaluations. Age-matched healthy volunteers will complete the same walking tests as controls. The study will use objective gait measurements and clinical walking tasks to characterize ambulation quality.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For people living with multiple sclerosis (pwMS):

1. Age at inclusion between =18 and =65 years old
2. Signed informed consent and ability to comply with study and follow-up.
3. Confirmed MS diagnosis according to McDonald criteria (2017)
4. Expanded Disability Status Scale EDSS = 6
5. Stable treatment for 2 months before inclusion (for both disease modifying and symptomatic therapies)
6. Ability and willingness to participate in and comply with all study procedures defined in the protocol
7. Subject will be eligible for enrollment in this study only if either affiliated to, or a beneficiary of a social security category

For Healthy volunteers :

1. Age at inclusion between =18 and =65 years old
2. Signed informed consent and ability to comply with study and follow-up.
3. Ability and willingness to participate in and comply with all study procedures defined in the protocol
4. Subject will be eligible for enrollment in this study only if either affiliated to, or a beneficiary of a social security category

Exclusion Criteria:

For pwMS:

1. Participants with a relapse within the past 3 months before the inclusion
2. Participants with significant cognitive disorders, limiting the understanding of the exercises to be performed or presence of apparent communication difficulties hindering the correct collection of data, as assessed by the investigator
3. Past or present pathology other than MS or surgery or trauma impacting gait, ambulatory function or upper limb function, as assessed by the investigator
4. Vulnerable adults: individuals subject to a legal protection measure (guardianship, limited guardianship, or judicial protection) or unable to express their consent.

For healthy volunteers (HV):

1. Participants with significant cognitive disorders, limiting the understanding of the exercises to be performed or presence of apparent communication difficulties hindering the correct collection of data, as assessed by the investigator
2. Past or present pathology or surgery or trauma impacting gait, ambulatory function or upper limb function, as assessed by the investigator
3. Vulnerable adults: individuals subject to a legal protection measure (guardianship, limited guardianship, or judicial protection) or unable to express their consent.

Where it's running

• CHU Lille
  Lille, France Recruiting

Study contacts

• Principal investigator: Patrick Vermersch — CHU Lille
• Study coordinator: Ferial Toumi
• Email: ferial.toumi@sysnav.fr
• Phone: +33 2 78 00 10 98

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.