SLT versus daily latanoprost to lower eye pressure in early to moderate open‑angle glaucoma and ocular hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observer‑masked, randomized controlled trial at Lagos State University Teaching Hospital will assign treatment‑naïve adults with early to moderate primary open‑angle glaucoma or ocular hypertension to either SLT or 0.005% latanoprost drops. A total of 138 eyes (69 per group) will be followed over 12 months to compare short‑term intraocular pressure (IOP) lowering, safety, and patient‑reported quality of life. Clinical assessments include serial IOP measurements, optic nerve imaging, visual field testing, and monitoring for adverse events, with observers masked to treatment assignment. The primary analysis will compare mean IOP reduction between groups and report differences in side effects and quality‑of‑life outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged 18years and above.
2. Patients newly diagnosed as Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT).
3. Patients with elevated IOP greater than 21mmHg (average of 3 measurements taken on 3 different clinic visits).
4. Patients categorized as early or moderate glaucoma POAG (cup -disc ratio 0.5 to 0.7, visual field analysis MD - 6dB to -12dB and disc damage likelihood score (DDLS) 5 to 7) on funduscopy, Optical coherence tomography, and fundus photograph
5. Patients who agree to participate in the study after informed consent.

Exclusion Criteria:

1. A prior medical, surgical, or laser treatment for glaucoma
2. Patients diagnosed with primary congenital glaucoma or secondary glaucoma
3. Advanced glaucoma (CDR greater than 0.8, visual field analysis MD more than -12dB and DDLS stage 8 and above)
4. Patients with cloudy cornea or corneal opacity that would impair the view of the anterior chamber angles, fundus, or give false IOP readings
5. Patients with media opacity, such as cataracts, vitreous haze, or vitreous hemorrhage that prevents examination of the posterior segment.
6. Patients who have undergone previous ocular surgeries (cataract surgery, trabeculectomy).
7. Patients with a history of ocular trauma or uveitis
8. Pregnant and lactating women.

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Where it's running

• Lagos State University teaching Hospital Eye Institute
  Ikeja, Lagos, Nigeria Recruiting

Study contacts

• Study coordinator: Anne I. Abang-Obi, MBBS
• Email: iyeundiandeye@gmail.com
• Phone: +234 7061339223

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.