Slowly digestible starch to raise GLP-1 and increase fullness
Slowly Digestible Carbohydrates for GLP-1 Secretion
NA · Purdue University · NCT07572513
This test will see if eating slowly digestible starch raises GLP‑1 hormone levels and makes healthy adults (18–45) feel fuller for longer.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 19 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Purdue University (other) |
| Locations | 1 site (West Lafayette, Indiana) |
| Trial ID | NCT07572513 on ClinicalTrials.gov |
What this trial studies
Healthy adults will consume one of three doses (20, 40, or 60 g) of raw corn starch or a maltodextrin control while fasting. Blood samples will be taken at baseline and 15, 30, 60, 90, 120, and 180 minutes after ingestion to measure total plasma GLP‑1, insulin, and glucose. Participants will report feelings of satiety at baseline and during follow-up time points, and researchers will test whether effects persist into a second meal. The goal is to identify the dose and duration of slowly digestible carbohydrate that maximizes GLP‑1‑mediated fullness.
Who should consider this trial
Good fit: Healthy adults aged 18–45 with BMI 18.5–24.9 kg/m2, fasting blood glucose ≤100 mg/dL, HbA1c ≤5.7%, not pregnant or nursing, without gastrointestinal disease or dairy/gluten allergies, and not using GLP‑1 medications or restrictive weight‑loss diets.
Not a fit: People with diabetes, a BMI outside 18.5–24.9, gastrointestinal disease, pregnant or nursing women, those taking GLP‑1 drugs or on weight‑loss diets, or individuals with dairy/gluten intolerance are excluded and unlikely to benefit from this healthy‑adult focused test.
Why it matters
Potential benefit: If successful, this could offer a simple food‑based way to boost GLP‑1, increase fullness, and help reduce calorie intake for weight management.
How similar studies have performed: Prior small human and animal studies suggest ileal‑delivered or slowly digestible starches can increase GLP‑1 and reduce appetite, but dose‑response testing in healthy adults is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Healthy population 2. BMI between 18.5 and 24.9 kg/m2 3. Adults 18 - 45 years old 4. Men or women 5. Able to read/speak English 6. Fasting blood glucose levels ≤100 mg/dL 7. HbA1c ≤ 5.7% Exclusion Criteria: 1. Participants with 18 \> Years of Age \> 45 will be excluded. 2. Subjects with 18.5 kg/m² \> BMI \> 24.9 kg/m² will be excluded. 3. Diabetic individuals will be excluded. 4. Individuals with history of gastrointestinal disease will be excluded from the study. 5. Pregnant or nursing women will also be excluded. 6. Individuals taking GLP-1 medications, or on weight-loss diets or restrictive eating patterns. 7. Individuals suffering from dairy or gluten intolerance or allergies will be excluded.
Where this trial is running
West Lafayette, Indiana
- Clinical Research Center at Purdue University — West Lafayette, Indiana, United States (RECRUITING)
Study contacts
- Study coordinator: Bruce R Hamaker, Ph.D.
- Email: hamakerb@purdue.edu
- Phone: 765-494-5668
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Blood Glucose, GLP-1, Satiety, Second Meal Intake, Healthy Participant Study, Slowly-Digestible Starch, Ileal-Digesting Starch, Dietary Starch