Skin carotenoid levels and immune aging
Official title: Carotenoids in the Skin and Immune Aging: a Pilot Observational Study
Run by Stanford University · NCT07221643 · Data updated 2026-11-12
This project will see if skin carotenoid levels are linked to immune health in healthy adults aged 18–30 and 65 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Stanford University Academic / other |
| Drugs / interventions | methotrexate, prednisone |
| Locations | 1 site (Redwood City, California) |
| Status | Recruiting |
| Started | October 9, 2025 |
| Main results expected | March 1, 2026 |
| Study ends | April 1, 2026 |
| Registry record updated | December 15, 2025 |
| Trial ID | NCT07221643 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18–30 or 65 and older without uncontrolled medical conditions, not pregnant or breastfeeding, and not using immune-modifying prescription medications are ideal candidates.
✕Probably not a fit
People with active skin disease on the upper extremity, recent use of immune-suppressing medications, uncontrolled medical conditions, or who are pregnant/breastfeeding are unlikely to qualify or gain direct benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will measure skin carotenoid content noninvasively and compare those levels with a range of immune-related health parameters in two age groups (18–30 and 65+). Eligible participants are healthy adults of all Fitzpatrick skin types who are not taking immune-altering prescription medications and do not have interfering skin disease on the upper extremity. The protocol excludes pregnant or breastfeeding people and those with uncontrolled medical conditions. Participants will attend the Stanford Health General Dermatology Clinic in Redwood City for measurements and specimen collection as specified by the study team.
Why it matters
Potential benefit: If successful, the work could identify a simple, noninvasive skin marker that reflects immune aging and help target monitoring or preventive efforts.
How similar studies have gone: Previous research has used noninvasive skin carotenoid measurements to reflect dietary antioxidant status, but applying those measures specifically to track immune aging is relatively novel and not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Willing and able to provide written informed consent * Age 18-30 years OR 65 years and older * Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed) * Fiitzpatrick I-VI (all skin types) Exclusion Criteria: * Pregnant or breastfeeding * uncontrolled medical conditions * Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis * Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others) * Unable to follow study protocol
Where it's running
-
Stanford Health - General Dermatology Clinic
Redwood City, California, United States Recruiting
Study contacts
- Study coordinator: Xiaochen Zhong, BA
- Email: xczhong@stanford.edu
- Phone: 408-816-0111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.