Clinical trial Recruiting at 1 site Observational Ages 18 and up

Skin carotenoid levels and immune aging

Official title: Carotenoids in the Skin and Immune Aging: a Pilot Observational Study

Run by Stanford University · NCT07221643 · Data updated 2026-11-12

This project will see if skin carotenoid levels are linked to immune health in healthy adults aged 18–30 and 65 and older.

More No Disease or Condition is Being Studied trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment40 (estimated)
SponsorStanford University
Academic / other
Drugs / interventionsmethotrexate, prednisone
Locations1 site (Redwood City, California)
StatusRecruiting
StartedOctober 9, 2025
Main results expectedMarch 1, 2026
Study endsApril 1, 2026
Registry record updatedDecember 15, 2025
Trial IDNCT07221643 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Healthy adults aged 18–30 or 65 and older without uncontrolled medical conditions, not pregnant or breastfeeding, and not using immune-modifying prescription medications are ideal candidates.

Probably not a fit

People with active skin disease on the upper extremity, recent use of immune-suppressing medications, uncontrolled medical conditions, or who are pregnant/breastfeeding are unlikely to qualify or gain direct benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will measure skin carotenoid content noninvasively and compare those levels with a range of immune-related health parameters in two age groups (18–30 and 65+). Eligible participants are healthy adults of all Fitzpatrick skin types who are not taking immune-altering prescription medications and do not have interfering skin disease on the upper extremity. The protocol excludes pregnant or breastfeeding people and those with uncontrolled medical conditions. Participants will attend the Stanford Health General Dermatology Clinic in Redwood City for measurements and specimen collection as specified by the study team.

Why it matters

Potential benefit: If successful, the work could identify a simple, noninvasive skin marker that reflects immune aging and help target monitoring or preventive efforts.

How similar studies have gone: Previous research has used noninvasive skin carotenoid measurements to reflect dietary antioxidant status, but applying those measures specifically to track immune aging is relatively novel and not yet proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Willing and able to provide written informed consent
* Age 18-30 years OR 65 years and older
* Healthy individuals without uncontrolled medical conditions (over the counter inhaled and topical steroids allowed)
* Fiitzpatrick I-VI (all skin types)

Exclusion Criteria:

* Pregnant or breastfeeding
* uncontrolled medical conditions
* Skin conditions on the upper extremity that would interfere with skin measurements of carotenoid levels such as active atopic dermatitis or psoriasis
* Concurrent use of medications that affect the immune system, within 4 weeks of enrollment (eg. prednisone, biologics, methotrexate, rapamycin, prescription topical steroids, prescription inhaled steroids, others)
* Unable to follow study protocol

Where it's running

  • Stanford Health - General Dermatology Clinic
    Redwood City, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.