Single-layer versus double-layer uterine closure after cesarean and myometrial thickness
Effects of Single-Layer Versus Double-Layer Cesarean Scar Repair on Myometrial Thickness and Associated Clinical Outcomes
This trial tests whether closing the uterus with one layer or two layers during cesarean leads to thicker, healthier scar tissue in women having a cesarean delivery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 102 (estimated) |
| Ages | 18 Years to 44 Years |
| Sex | Female |
| Sponsor | Ankara City Hospital Bilkent Academic / other |
| Locations | 1 site (Ankara, Not Valid) |
| Trial ID | NCT07323355 on ClinicalTrials.gov |
What this trial studies
This interventional trial compares single-layer and double-layer uterine closure techniques in women undergoing cesarean delivery at Ankara Bilkent City Hospital. Eligible participants receive one of the two closure methods during their cesarean operation and are followed after surgery. Myometrial thickness and scar characteristics will be measured using postoperative ultrasound and clinical follow-up. The protocol excludes women with chronic systemic disease, placenta previa/accreta, anterior uterine fibroids, nonstandard uterine incisions, or predicted obstetric hemorrhage.
Who should consider this trial
Good fit: Women aged 18–44 who are delivering by cesarean at the study hospital, are clinically healthy on routine preoperative tests, and meet the listed inclusion criteria.
Not a fit: Women with chronic illnesses, suspected or confirmed placenta previa/accreta, anterior wall myomas, nonstandard uterine incisions, predicted obstetric hemorrhage, or those who will not deliver at the study site are unlikely to benefit from participation.
Why it matters
Potential benefit: If one closure method produces reliably thicker myometrium and fewer scar defects, it could reduce postmenstrual symptoms and lower the risk of serious future complications like uterine rupture or placenta accreta.
How similar studies have performed: Previous comparisons of single- versus double-layer uterine closure have shown mixed results and there is no clear consensus on which technique best prevents scar defects.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female participants aged 18-44 years. * Undergoing cesarean delivery at the study hospital's Obstetrics and Gynecology clinic. * Evaluated as clinically eligible based on history, physical examination, abdominal ultrasonography, and routine preoperative laboratory tests, including: Complete blood count (CBC), biochemical profile, prothrombin time (PT), activated partial thromboplastin time (aPTT), blood group determination. No abnormalities detected in the above assessments. Exclusion Criteria: \- Presence of chronic diseases, including: Rheumatologic diseases, renal failure, vascular malformations, hypertension, cardiac disease, diabetes mellitus, obesity, thyroid disease, congenital hematologic disorders. * Suspected or confirmed placenta previa or placenta accreta spectrum. * Clinical chorioamnionitis. * Anterior wall uterine myomas. * History of low transverse nonstandard uterine incision. * Predicted obstetric hemorrhage or other intraoperative complications.
Where this trial is running
Ankara, Not Valid
- Ankara Bilkent City Hospital — Ankara, Not Valid, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Merve Didem Eşkin Tanrıverdi — Ankara City Hospital Bilkent
- Study coordinator: Merve Didem Eşkin Tanrıverdi, MD
- Email: mrvddm@hotmail.com
- Phone: +905354071467
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.