Simvastatin placed inside the root canal for failed single‑rooted teeth with periapical lesions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study applies simvastatin as an intracanal medication in symptomatic failed endodontic cases of single‑rooted teeth with periapical lesions measuring 2–8 mm in patients aged 20–40. Eligible teeth will be re‑treated and receive simvastatin placed inside the prepared root canal, with follow‑up clinical and radiographic exams to monitor healing. Microbiological targets include Enterococcus faecalis and biofilm reduction, and inflammatory markers such as IL‑1β, TNF‑α, and PGE2 may be measured to document anti‑inflammatory effects. Standard exclusions include pregnancy, non‑restorable teeth, advanced periodontal disease, root fractures, prior endodontic mishaps, and known drug sensitivity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients had anon contributory medical history.
* Patients of age categories between 20 to 40 years old, with no physical disability or psychological problems.
* Single rooted teeth with type I root canal anatomy.
* Symptomatic cases of failed endodontic treatment with radiographic evidence of periapical bone loss, and the lesion size ranging from 2mm up to 8mm.

Exclusion Criteria:

* Patients with known sensitivity to the pharmaceutical used in this trial
* Patients with former endodontic mishaps (as ledges, transportations, perforations or separated instruments)
* Non restorable teeth
* Presence of an associated sinus tract.
* Advanced periodontal involvement
* Teeth representing root fracture.
* Pregnant women

Where it's running

• Faculty of Dental Medicine for Girls, Al-Azhar University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Hadeer Maher Mostafa Mohamed, MSc
• Email: hadeer.maher@den.suezuni.edu.eg
• Phone: +201024990619

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.