SHR-1501 plus adebrelimab for advanced or metastatic solid tumors

Phase I/II Clinical Study on the Tolerability, Safety and Efficacy of SHR-1501 Combined With Adbelizumab in Patients With Malignant Tumors

This trial will test whether combining SHR-1501 and adebrelimab can shrink tumors or control disease in adults with advanced or metastatic solid tumors who have exhausted standard treatments.

Quick facts

• Phase: PHASE1; PHASE2
• Study type: Interventional
• Enrollment: 203 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Shanghai Hengrui Pharmaceutical Co., Ltd. (industry)
• Drugs / interventions: chemotherapy, immunotherapy, radiation, prednisone, adibelizumab
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT07073534 on ClinicalTrials.gov

What this trial studies

This open-label, multicenter Phase I/II trial enrolls adults with histologically or cytologically confirmed advanced or metastatic solid tumors that have progressed after standard treatment or lack standard options. The study is conducted in three parts—dose escalation to identify a safe dose, dose expansion to further evaluate safety and early activity, and an efficacy expansion to measure objective response rate. Eligible participants must have at least one measurable lesion per RECIST 1.1, ECOG performance status 0–1, and expected survival >3 months, and will receive SHR-1501 in combination with adebrelimab. Primary goals are to measure objective response rate (ORR), characterize safety and tolerability, and determine a recommended Phase II dose (RP2D).

Who should consider this trial

Good fit: Adults 18–75 years with histologically or cytologically confirmed inoperable locally advanced or metastatic solid tumors, at least one measurable lesion, ECOG 0–1, disease progression after or lack of standard therapy, and expected survival >3 months.

Not a fit: Patients with symptomatic or active CNS metastases, another malignancy within five years, uncontrolled tumor-related pain, poor performance status, or those suitable for curative therapy are unlikely to benefit from this early-phase combination.

Why it matters

Potential benefit: If successful, the combination could offer a new treatment option that shrinks tumors or prolongs disease control for patients with advanced cancers who have few alternatives.

How similar studies have performed: Other early-phase trials combining immune checkpoint inhibitors with investigational agents have shown responses in some tumor types, but this specific SHR-1501 plus adebrelimab combination is early-stage and not yet proven.

Eligibility criteria

Inclusion Criteria:

1. Voluntarily participate in this clinical study, understand the research procedures and be able to sign the informed consent form in person.
2. Age: 18 to 75 years old (including both ends), gender not limited.
3. Subjects with locally advanced or metastatic solid tumors that have been histologically or cytologically confirmed to be inoperable for radical surgery or radical chemoradiotherapy, whose disease progresses after standard treatment, or who have no standard treatment plan, or are not suitable for standard treatment.
4. According to the efficacy evaluation criteria for Solid tumors (RECIST 1.1), there is at least one measurable lesion;
5. The ECOG physical condition score is 0 or 1.
6. The expected survival time is more than 3 months;

Exclusion Criteria:

1. Symptomatic or active central nervous system (CNS) tumor metastasis;
2. Other malignant tumors within five years before the first use of study drugs;
3. Uncontrolled tumor-related pain judged by the investigator;
4. Severe cardiovascular and cerebrovascular diseases;
5. Significant clinical bleeding symptoms within 3 months before the first study drug, and obvious fresh hemoptysis within 1 month before the first study drug;
6. Uncontrollable pleural effusion and/or ascites judged by the study or pleural effusion and/or ascites requiring intervention within 7 days before the first treatment
7. History of idiopathic pulmonary fibrosis, organizing pneumonia (such as bronchiolitis obliterans), drug-related pneumonia requiring steroid therapy;,or active pneumonia at screening; or other moderate to severe pulmonary diseases that significantly affect pulmonary function;
8. Severe infection within 4 weeks before the start of study treatment
9. History of immunodeficiency
10. Used corticosteroids (\>10 mg/day prednisone or equivalent) or other systemic immunosuppressants within 14 days before the first study drug.
11. Patients with active pulmonary tuberculosis infection within 1 year before enrollment as determined by medical history or imaging examination, or patients with a history of active pulmonary tuberculosis infection more than 1 year ago but without formal treatment
12. Patients whose adverse events caused by previous treatment have not recovered to ≤CTCAE grade 1
13. Patients whose previous treatment washout does not meet the following requirements: Patients who have received chemotherapy, biological therapy, targeted therapy, immunotherapy, or other unlisted clinical research drugs and other anti-tumor treatments within 4 weeks before the first use of the study drug
14. Patients who have experienced CTCAE grade 4 or grade 3 immune-related adverse events lasting for 4 weeks or longer after previous use of immune checkpoint inhibitors, or immune-related adverse events that led to treatment discontinuation, are not eligible for enrollment in this study.
15. Patients who have received \>30 Gy chest radiotherapy within 24 weeks before the first use of the study drug, patients who have received \>30 Gy non-chest radiotherapy within 4 weeks before the first use of the drug (subjects who have completed brain metastasis radiotherapy 14 days before the first use of the drug can be enrolled), and patients who have received ≤30 Gy within 14 days before the first use of the drug Gy of palliative radiation;
16. Subjects who have undergone surgery on important organs (excluding puncture biopsy) within 4 weeks before the first use of the study drug, have had significant trauma, or need to undergo elective surgery during the trial;
17. Active, known or suspected autoimmune diseases and history of autoimmune diseases.
18. Using attenuated live vaccines within 28 days before the first use of the study drug, or anticipating the need to use attenuated live vaccines during the study treatment;
19. Pregnant or lactating women or female subjects who plan to become pregnant during the study and within 6 months after the last use of the study drug;
20. Those who are known to be allergic to any component or excipient of the study drug; or have a history of severe allergic reactions to other monoclonal antibodies/fusion protein drugs;
21. The investigators judge that the subjects have other factors that may affect the study results or force the termination of this study, such as alcoholism, drug abuse, other serious diseases (including mental illness) requiring combined treatment, serious abnormal laboratory test values, family or social factors, and other situations that may affect the safety of the subjects or the collection of trial data.

Where this trial is running

Guangzhou, Guangdong

• Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China (RECRUITING)

Study contacts

• Study coordinator: Fei Qiu

Conditions: Patients With Advanced or Metastatic Malignant Tumors