Shortening infusion times for cancer immunotherapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to evaluate the safety of reducing infusion times for patients receiving various monoclonal antibodies, including nivolumab, pembrolizumab, ipilimumab, trastuzumab, bevacizumab, durvalumab, and atezolizumab. After two cycles with standard infusion durations, the study will gradually shorten the infusion times to 15 and then 10 minutes, provided that no infusion reactions occur. Patient satisfaction will also be assessed throughout the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Starting treatment with monoclonal antibodies: nivolumab, pembrolizumab ipilimumab, bevacizumab, trastuzumab, durvalumab or atezolizumab.
* 18 years and older.
* No known history of increased susceptibility to immunological reactions.
* Subject is able and willing to sign the Informed Consent Form prior to screening evaluations.

Exclusion Criteria:

* Other research medication within 4 weeks of the start of the study.
* Inclusion in medical research in which the administration of medication should follow its stated times and dosages of infusions
* Dosage deviates from standard protocol
* Patients whom receive drugs through a central venous catheter (and for example porth-a-cath).

Where it's running

• Isala Hospital
  Zwolle, Netherlands Recruiting

Study contacts

• Study coordinator: Elianne CS de Boer
• Email: polioncologie@isala.nl
• Phone: +31886245000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.