Short-term effects of blood pressure medicines on balance and fall risk
Official title: The Effect of Antihypertensive Medication Use on Fall Risk: A Randomized Controlled Trial
Run by Abant Izzet Baysal University · NCT07099677 · Data updated 2026-11-12
This trial tests whether three common blood pressure medicines (a beta blocker, an ACE inhibitor, and a calcium channel blocker) change balance, dizziness, and short-term fall risk in adults newly diagnosed with high blood pressure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 186 (estimated) |
| Sponsor | Abant Izzet Baysal University Academic / other |
| Locations | 1 site (Bolu) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | February 12, 2026 |
| Trial ID | NCT07099677 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18–75 with newly diagnosed primary hypertension who have not used antihypertensive drugs, can walk without assistive devices, and have no neurological, vestibular, orthopedic, or psychiatric conditions affecting balance.
✕Probably not a fit
People with secondary hypertension, known vestibular disorders, current use of medications that affect balance (e.g., sedatives or psychotropics), cognitive impairment, or inability to attend follow-up visits are unlikely to benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial assigns adults aged 18–75 with newly diagnosed primary hypertension to metoprolol, ramipril, or amlodipine and follows them for four weeks. Objective balance is measured with the Biodex Balance System (including Fall Risk Test, Postural Stability Test, and CTSIB) and subjective symptoms are recorded with the Dizziness Handicap Inventory and Falls Efficacy Scale. Assessments occur at baseline, 2 weeks, and 4 weeks after starting medication to capture short-term effects on postural stability and fear of falling. Participants with prior antihypertensive use or conditions affecting balance are excluded to isolate medication-related effects.
Why it matters
Potential benefit: If successful, the results could help clinicians choose initial blood pressure medicines that reduce dizziness and short-term fall risk.
How similar studies have gone: Some prior research has shown certain antihypertensive classes can cause dizziness or orthostatic hypotension, but randomized direct comparisons of short-term balance and fall risk are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 18 and 75 years * Newly diagnosed with primary hypertension * No prior use of antihypertensive medication * No history of neurological, vestibular, orthopedic, or psychiatric conditions affecting balance * Able to walk independently without assistive devices * Provided written informed consent to participate in the study Exclusion Criteria: * Secondary hypertension * Known diagnosis of vestibular disorders (e.g., BPPV, Ménière's disease) * Use of medications that may affect balance (e.g., sedatives, psychotropic drugs) * History of falls due to trauma unrelated to balance * Cognitive impairment preventing proper test participation * Inability to complete the assessments at follow-up timepoints (2nd and 4th week)
Where it's running
-
Bolu Abant Izzet Baysal University, Izzet Baysal Training and Research Hospital
Bolu, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Alp Ozel, PT, PhD — Abant Izzet Baysal University
- Study coordinator: Alp Ozel, PT, PhD
- Email: alpozel@ibu.edu.tr
- Phone: +903742534520
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Adding proprioceptive neuromuscular facilitation to Otago exercises to reduce fall risk in people with type 2 diabetes
This tests whether adding PNF to standard Otago balance and strength exercises helps people aged 50–75 with type 2 diabetes and peripheral neuropathy reduce their risk of falling.
-
Using low-dose aspirin after preeclampsia to improve recovery
This study is testing if taking low-dose aspirin for six months after having preeclampsia can help new moms recover better by improving their blood pressure and blood vessel function.
-
IMB-guided health education to boost medication taking and blood pressure control in adults with hypertension
This study tests a health-literacy program based on Information-Motivation-Behavioral Skills to help adults with hypertension who don’t take their medicines regularly to take them more consistently and better control their blood pressure.
-
Renal Nerve Stimulation to Help Blood Pressure in AF and HFpEF
This study tests whether stimulating the kidneys with a catheter can safely lower blood pressure in adults with atrial fibrillation and HFpEF who also have hypertension.
-
Hypertension: Does Education Help Patients Manage Blood Pressure Better?
This study tests whether structured patient education improves blood pressure control and self-management in adults with hypertension who speak Turkish.
-
High BMI and periodontitis in Thai adults under 60
This study tests how common high BMI and periodontitis are among Thai adults aged 18–59 and what factors are linked to them.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.