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Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Shock wave therapy to encourage new blood vessels in coronary artery disease

Official title: Use of Shock Wave Therapy for Neo-Vascularisation in Non-critical Coronary Artery Disease: Validation by Quantitative Cardiac MRI Perfusion

Run by The University of Hong Kong · NCT07068399 · Data updated 2026-11-12

This will test extracorporeal shock wave therapy to see if it improves blood flow and heart pumping in people with symptomatic coronary artery disease who do not have major blockages.

More Coronary Artery Disease trials

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment100 (estimated)
SponsorThe University of Hong Kong
Academic / other
Locations1 site (Hong Kong)
StatusRecruiting
StartedSeptember 1, 2020
Main results expectedApril 30, 2027
Study endsApril 30, 2027
Registry record updatedNovember 9, 2026
Trial IDNCT07068399 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with symptoms of coronary artery disease who do not have obstructive coronary lesions, have LVEF ≥40%, can receive contrast stress cardiac MRI and are not pregnant or otherwise ineligible by the listed exclusions.

Probably not a fit

Patients with obstructive coronary artery disease, LVEF <40%, recent myocardial infarction, contraindications to contrast stress cardiac MRI or adenosine, severe renal impairment (eGFR <30), or who are hemodynamically unstable are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized controlled trial that gives cardiac extracorporeal shock wave therapy (CSWT) to one group and compares outcomes to a control group, with measurements taken before and after treatment. The main measures are quantitative myocardial perfusion and left ventricular function using stress contrast cardiac MRI, a non‑radiation method. Participants are adults with symptomatic but non‑obstructive coronary artery disease and left ventricular ejection fraction ≥40%. The trial uses MRI perfusion to provide objective, segmental measures of blood flow that previous CSWT studies mostly assessed with SPECT or PET.

Why it matters

Potential benefit: If successful, CSWT could increase blood flow to under‑perfused heart muscle, reduce angina symptoms, and improve heart pumping, potentially delaying or reducing the need for invasive procedures.

How similar studies have gone: Previous meta-analyses of 39 CSWT reports (about 1,189 patients) found consistent improvements in angina and many reports of better perfusion and left ventricular function by SPECT/PET, but cardiac MRI has not been widely used to confirm those effects.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion criteria:

* Patients with symptoms of coronary artery disease
* Patients without obstructive coronary artery disease
* with LVEF not \< 40%.

Exclusion criteria:

* Age \< 18 years,
* Pregnancy or lactation.
* Contraindication to contrast enhanced stress Cardiac Magnetic Resonance (eg. Estimated GFR \<30ml/min/1.73m2, severe allergy to gadolinium based contrast agent, contraindication to adenosine)
* Life expectancy \<24 months
* Haemodynamically unstable
* Participation in other clinical trial within 6 months of enrollment.
* Recent myocardial infarction within 6 months.
* Unable to consent to or perform components of the study.

Where it's running

  • HKU Li Ka Shing Faculty of Medicine
    Hong Kong, Hong Kong     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Coronary Artery Disease 385The University of Hong Kong 192
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.