Shear wave elastography to predict shock wave treatment success for pediatric kidney stones

Evaluating Shear Wave Elastography as a Predictor of Extracorporeal Shock Wave Lithotripsy Outcomes and Stone Composition in Children "A Prospective Study"

This study will test whether shear wave elastography, an ultrasound method that measures stiffness, can help predict if shock wave treatment will work for children with 6–20 mm kidney stones without using CT radiation.

Quick facts

• Study type: Observational
• Enrollment: 108 (estimated)
• Ages: 1 Year to 18 Years
• Sex: All
• Sponsor: Beni-Suef University (Academic / other)
• Drugs / interventions: radiation
• Locations: 1 site (Banī Suwayf)
• Trial ID: NCT07506031 on ClinicalTrials.gov

What this trial studies

This prospective observational study will perform shear wave elastography (SWE) measurements on pediatric patients with a single renal stone 6–20 mm before they undergo extracorporeal shock wave lithotripsy (ESWL). Patients will be followed for three months after ESWL to document treatment success and the number of sessions required. The study will compare SWE measurements with CT-derived Hounsfield units and with stone composition when available. Secondary analyses will explore correlations between SWE, HU, stone composition, and ESWL outcomes.

Who should consider this trial

Good fit: Children under 18 years old with a single renal stone measuring 6–20 mm who are scheduled to undergo ESWL as first-line treatment and who do not have an indwelling ureteral stent, abnormal renal anatomy, active UTI, or coagulopathy are ideal candidates.

Not a fit: Patients with ureteral stones, multiple or complex stone burden, abnormal renal anatomy, indwelling ureteral stents, active urinary tract infection, or bleeding disorders are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, SWE could provide a noninvasive, radiation-free way to predict ESWL success and help tailor treatment plans for children with kidney stones.

How similar studies have performed: Early pilot studies and some adult data using SWE to characterize stone stiffness or renal tissue show promise, but the approach remains experimental and not yet widely validated for predicting ESWL outcomes in children.

Eligibility criteria

Inclusion Criteria:

* Inclusion criteria:

  1. Single Renal stones measured 6- 20 mm in maximal dimension.
  2. ESWL will be planned as the first line of treatment.

Exclusion Criteria:

1. Patients with internal ureteral stent.
2. ureteral stones.
3. abnormal renal anatomies (pelvic kidney, horseshoe kidney, and rotational anomaly).
4. active UTI at time of ESWL.
5. coagulopathy .

Exclusion Criteria:

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Where this trial is running

Banī Suwayf

• faculty of medicine Beni Suef university hospital — Banī Suwayf, Egypt (Recruiting)

Study contacts

• Study coordinator: Mahmoud Abdallah Mahmoud, MD of urology

Conditions Pediatric Urolithiasis