Sevoflurane versus desflurane for lung protection during robotic abdominal surgery
Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study
This trial will test whether sevoflurane or desflurane better preserves lung mechanics in adults having elective robotic-assisted abdominal surgery with protective mechanical ventilation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 87 Years |
| Sex | All |
| Sponsor | National and Kapodistrian University of Athens Academic / other |
| Locations | 1 site (Athens) |
| Trial ID | NCT07304479 on ClinicalTrials.gov |
What this trial studies
The trial compares two commonly used inhaled anesthetics—sevoflurane and desflurane—in adults aged 18–87 undergoing elective robotic-assisted abdominal procedures with lung-protective mechanical ventilation. Eligible participants have ASA physical status I–III and no significant respiratory, renal, or cardiac comorbidities. Each participant will receive one of the volatile agents during surgery and intraoperative respiratory mechanics and markers of alveolar inflammation will be recorded. Outcomes will be compared between groups at predefined intraoperative and early postoperative time points to determine differences in lung function and inflammatory response.
Who should consider this trial
Good fit: Adults aged 18–87 scheduled for elective robotic-assisted abdominal surgery with ASA physical status I–III and without significant respiratory, renal, or cardiac disease are ideal candidates.
Not a fit: Patients with ASA IV or V, emergency surgery, renal insufficiency, clinically significant respiratory disease, cardiomyopathy, or uncontrolled hypertension are excluded and unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could identify which anesthetic better protects the lungs during robotic abdominal surgery and reduce intraoperative lung injury and postoperative respiratory complications.
How similar studies have performed: Previous studies in abdominal surgery suggest inhaled anesthetics can reduce alveolar inflammation and aid lung protection, but direct comparisons of sevoflurane versus desflurane specifically in robotic-assisted abdominal procedures are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 to 87 years * Undergoing elective robotic-assisted abdominal surgery * ASA physical status I-III Exclusion Criteria: * ASA IV or V * Emergency surgery * Renal insufficiency * Clinically significant respiratory disease * Cardiomyopathy * Uncontrolled hypertension
Where this trial is running
Athens
- Aretaieion University Hospital — Athens, Greece (Recruiting)
Study contacts
- Study coordinator: Aliki Tympa, MD,PhD
- Email: alikitympa@med.uoa.gr
- Phone: 00306955487575
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.