Sevoflurane versus desflurane effects on optic nerve sheath diameter during laparoscopic hysterectomy
Comparison of the Effects of Sevoflurane and Desflurane Used for Anesthesia Maintenance on Optic Nerve Sheath Diameter in the Trendelenburg Position
This trial will test whether sevoflurane or desflurane causes different changes in optic nerve sheath diameter in people having laparoscopic hysterectomy with Trendelenburg positioning.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | Female |
| Sponsor | Medipol University Academic / other |
| Locations | 1 site (Istanbul) |
| Trial ID | NCT07525648 on ClinicalTrials.gov |
What this trial studies
This prospective, interventional trial enrolls patients undergoing laparoscopic hysterectomy with bilateral oophorectomy and randomizes them to receive either sevoflurane or desflurane for general anesthesia. Optic nerve sheath diameter (ONSD) will be measured by ultrasound before, during pneumoperitoneum and Trendelenburg positioning, and after surgery. Hemodynamic parameters will be recorded alongside ONSD measurements and patients will be monitored for postoperative neurological complications. The primary comparison is the between-group difference in ONSD values, with secondary analyses relating ONSD changes to blood pressure, heart rate, and any neurological events.
Who should consider this trial
Good fit: Adults scheduled for laparoscopic hysterectomy with bilateral oophorectomy under general anesthesia who do not meet the exclusion criteria are ideal candidates.
Not a fit: Patients on beta-blockers or diuretics, with severe heart failure, diabetes with ocular or neurologic complications, prior cardiac/eye/brain/thoracic surgery, or known hydrocephalus, glaucoma, intracranial mass, or stroke are excluded and are unlikely to benefit from these results.
Why it matters
Potential benefit: If successful, the results could help anesthesiologists choose the inhaled agent that limits increases in intracranial pressure during laparoscopic procedures.
How similar studies have performed: Previous work has shown ultrasound ONSD can reflect changes in intracranial pressure during laparoscopy and that inhaled anesthetics affect cerebral hemodynamics, but direct head-to-head comparisons between sevoflurane and desflurane in this setting are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients planned for laparoscopic hysterectomy bilateral oophorectomy surgery under general anesthesia. Exclusion Criteria: * Patients receiving beta-blocker or diuretic treatment. * Patients with severe heart failure. * Patients diagnosed with diabetes with ocular or neurological complications. * Patients who have undergone cardiac surgery, eye surgery, brain surgery, or thoracic surgery. * Patients with a history of hydrocephalus, glaucoma, intracranial mass, and stroke.
Where this trial is running
Istanbul
- Istanbul Medipol University — Istanbul, Turkey (Türkiye) (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.