Sevoflurane versus desflurane during laparoscopic gallbladder removal
Laparoscopic Cholecystectomy Patients: Effect of Sevoflurane vs. Desflurane on Mechanical Power - A Prospective, Randomized, Controlled Trial
This trial tests whether sevoflurane or desflurane results in lower intraoperative mechanical power in adults having elective laparoscopic gallbladder removal.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 138 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Konya City Hospital Academic / other |
| Locations | 1 site (Konya, Konya) |
| Trial ID | NCT07295158 on ClinicalTrials.gov |
What this trial studies
This single-center, prospective, randomized, assessor-blinded trial will compare sevoflurane and desflurane anesthesia in adults aged 18–65 undergoing elective laparoscopic cholecystectomy. Mechanical power will be calculated at three standardized intraoperative time points using a validated formula, and driving pressure and early postoperative respiratory events (desaturation, laryngospasm, bronchospasm, cough) are prespecified secondary outcomes. Key exclusions include severe COPD, uncontrolled asthma, decompensated heart failure, prior lung surgery, morbid obesity (BMI >35), and pregnancy. The protocol aims to determine whether one volatile agent produces lower ventilatory mechanical stress during routine laparoscopic gallbladder surgery.
Who should consider this trial
Good fit: Adults 18–65 years old with ASA physical status I–II scheduled for elective laparoscopic cholecystectomy who can give informed consent are ideal candidates.
Not a fit: Patients with severe pulmonary disease, decompensated heart failure, prior lung surgery, morbid obesity (BMI >35), or pregnancy are excluded and therefore unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help anesthesiologists choose the agent that reduces ventilatory mechanical stress and possibly lower rates of early postoperative respiratory complications.
How similar studies have performed: Prior work has compared sevoflurane and desflurane for airway reactivity and some lung mechanics metrics, but direct intraoperative mechanical power comparisons are limited, making this a relatively novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 18-65 years ASA Physical Status I-II Scheduled for elective laparoscopic cholecystectomy Able to provide written informed consent Exclusion Criteria: Known hypersensitivity or contraindication to study medications (sevoflurane or desflurane) Severe chronic obstructive pulmonary disease (COPD) Uncontrolled bronchial asthma Decompensated heart failure (NYHA Class III-IV) History of prior lung surgery Morbid obesity (BMI \> 35 kg/m²) Pregnancy Refusal to participate or inability to provide informed consent \-
Where this trial is running
Konya, Konya
- Konya City Hospital — Konya, Konya, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Nuran AKINCI EKİNCİ
- Email: nurandr@yahoo.com
- Phone: +905337637180
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.