Serum S100B and BDNF levels in women with fibromyalgia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This cross-sectional observational study compares serum S100B and BDNF in women diagnosed with fibromyalgia (2016 ACR criteria) and age- and sex-matched healthy controls. Participants will complete questionnaires on symptoms, central sensitization, and sleep, and provide a single blood sample for biomarker measurement. Analyses will compare biomarker levels between groups and test associations between those levels and measures of central sensitization and sleep quality. The study is designed to clarify biomarker patterns rather than to alter clinical care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female participants aged between 18 and 50 years

Diagnosis of fibromyalgia according to 2016 American College of Rheumatology (ACR) criteria

Symptoms present for at least 3 months

Ability to understand and complete study questionnaires

Provision of written informed consent

For healthy controls:

No diagnosis of fibromyalgia or chronic widespread pain

No known systemic disease

Exclusion Criteria:

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Where it's running

• Kanuni Sultan Süleyman Training and Research Hospital
  Istanbul, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Zeynep Karakuzu Güngör, M.D — Kanuni Sultan Süleyman Training and Research Hospital
• Study coordinator: Zeynep Karakuzu Güngör, M.D
• Email: zeynepkarakuzu@hotmail.com.tr
• Phone: 905077750375

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.