Sensory rehabilitation for taste and smell issues in chemotherapy patients
Impact of a Sensory Rehabilitation Program on Olfactory-gustatory Alterations in Patients Treated With Chemotherapy for Haematological Cancer
This study is testing a program to help cancer patients who have had chemotherapy improve their sense of taste and smell to feel better and enjoy food again.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospital, Montpellier Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT04716153 on ClinicalTrials.gov |
What this trial studies
This study proposes a sensory rehabilitation program aimed at reducing olfactory and gustatory alterations in patients who have undergone chemotherapy for hematological cancers. It addresses the significant impact of taste and smell disturbances on quality of life, emotional well-being, and nutrition. The program includes multifactorial sensory rehabilitation workshops, usual care, and assessments through tests and questionnaires. The hypothesis is that this intervention will improve patients' sensory experiences and overall quality of life.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 75 who have completed chemotherapy for hematological cancer and are experiencing olfactory or gustatory disorders.
Not a fit: Patients with pre-existing eating disorders, severe performance status, or those currently involved in other clinical trials related to taste or olfaction may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly enhance the quality of life and nutritional status of patients recovering from chemotherapy.
How similar studies have performed: While there is limited international clinical guidance on managing taste and olfactory disturbances in this context, the proposed approach is based on recent research and aims to fill existing gaps.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and ≤ 75 years old * Patient with olfactory or gustatory disorders * Patient who has completed chemotherapy for haematological cancer Exclusion Criteria: * Eating disorder known prior to anti-cancer treatment, bulimic, anorexic or binge eating disorder (DSM-V criteria) * Refusal to sign the free and informed consent * Hypersensitivity to one of the components of liposomal sprays (Liposaliva® or liponasal®) * COVID + patient in the previous 3 months * Performance status ECOG 3 or 4 * Patient included in another clinical trial modifying taste / olfaction * Artificial nutrition post-chemotherapy * Known food allergies * Having a reading level in French that may interfere with a good understanding of the protocol and the questionnaires * Presenting visual or hearing deficits uncorrected to normal and which may affect the proper completion of the questionnaires * Patient under curatorship or tutorship. * Patient deprived of liberty * Pregnant or breastfeeding patient * Not be affiliated with a French social security scheme or beneficiary of such a scheme
Where this trial is running
Montpellier
- Hematology Department, University Hospital Center — Montpellier, France (Recruiting)
Study contacts
- Study coordinator: Franciane PAUL, Dr.
- Email: f-paul@chu-montpellier.fr
- Phone: 0033467338260
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.