Self-collection of Pap smears to improve cervical cancer screening in rural Alabama

Self-Collection of the Pap Smear as Agency: A Novel Way to Improve Refractory Low Cervical Cancer Screening Rates in Rural Alabama

Not applicable Interventional University of Alabama at Birmingham · NCT04093388

This study is testing if women in rural Alabama can accurately collect their own Pap smears at home to help improve cervical cancer screening rates.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment250 (estimated)
Ages21 Years to 65 Years
SexFemale
SponsorUniversity of Alabama at Birmingham Academic / other
Locations3 sites (Birmingham, Alabama and 2 other locations)
Trial IDNCT04093388 on ClinicalTrials.gov

What this trial studies

This study investigates whether self-administered Pap smears are as accurate as those collected by healthcare providers. Participants will provide both self-collected and provider-collected specimens, which will be analyzed without the pathologist knowing which is which. The goal is to determine if self-collection can enhance cervical cancer screening rates in rural areas. The study aims to empower women by providing them with the option to collect their own samples.

Who should consider this trial

Good fit: Ideal candidates are women aged 21 to 65 who require routine cervical cancer screening.

Not a fit: Patients with a prior history of cervical cancer, a positive Pap smear, or those who have had a total hysterectomy will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly increase cervical cancer screening rates among women in rural areas.

How similar studies have performed: Other studies have shown promise in self-collection methods for cervical cancer screening, indicating potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Female of at least 21 years of age and not over 65 presenting who need routine cervical cancer screening per national guidelines.

Exclusion Criteria:

* prior history of cervical cancer or a positive Pap smear, have had a total hysterectomy (removal of uterus and cervix), or currently enrolled in any other cancer prevention study.

Where this trial is running

Birmingham, Alabama and 2 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Cervical CancerPap smearPapanicolaouself-collectioncervical cancer screening
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.