Selective stimulation of the vagus nerve using electrical impedance tomography

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to explore the functional anatomy of the cervical vagus nerve in humans to enable selective stimulation for treating various vagus nerve-related conditions, including epilepsy. By identifying specific fascicles within the nerve that innervate different organs, the study seeks to minimize off-target effects associated with traditional vagus nerve stimulation. The methodology involves using nerve cuff electrodes and electrical impedance tomography to achieve spatially selective stimulation. This innovative approach could lead to more effective treatments for conditions like epilepsy while reducing side effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age over 18
* Written informed consent by patient or proxy
* Clinical diagnosis of disorder affected directly or indirectly or will possibly respond to vagus nerve stimulation

Exclusion Criteria:

* Aged 17 and below
* Unfortunately, it is unlikely that interpreters of all languages will be available in the unit so persons who cannot understand verbal explanation in English and for whom we could not find a suitable consultee would have to be excluded from the study.

Where it's running

• National Hospital of Neurology and Neurosurgery
  London, Greater London, United Kingdom Recruiting

Study contacts

• Principal investigator: Kirill Aristovich — University College, London
• Study coordinator: Kirill Aristovich
• Email: k.aristovich@ucl.ac.uk
• Phone: +44 (0) 20 3549 5035

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.