Selective removal of decayed tissue in back teeth

Carious Tissue Selective Removal on Permanent Posterior Teeth. A Randomized Controlled Clinical Study.

Not applicable Interventional Universitat Internacional de Catalunya · NCT04533113

This study tests whether using different materials to remove decayed tissue from back teeth helps patients feel better and have better results over time.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment111 (estimated)
Ages18 Years to 75 Years
SexAll
SponsorUniversitat Internacional de Catalunya Academic / other
Locations1 site (Sant Cugat del Vallès, Barcelona)
Trial IDNCT04533113 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of selectively removing carious tissue from deep lesions in posterior teeth using three different liner materials: VitreBond ™Plus, BioDentine™, and Theracal™ LC. It is a prospective randomized controlled study conducted at the Universitat Internacional de Catalunya, where patients will be monitored for post-operative pain and clinical success over one, two, and five years. The study aims to determine if there are significant differences in treatment success rates among the three materials used.

Who should consider this trial

Good fit: Ideal candidates are patients with posterior teeth diagnosed with normal pulp or reversible pulpitis who can provide informed consent.

Not a fit: Patients with systemic diseases, irreversible pulpitis, or those who are pregnant may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved treatment outcomes and reduced post-operative pain for patients with deep dental caries.

How similar studies have performed: Other studies have explored selective carious tissue removal, but the specific comparison of these three materials is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients that demonstrate understanding of the study and willingness to participate as evidenced by signing the voluntary informed consent and received a signed and dated copy of the informed consent form.
* Understands and is willing to comply with all study procedures and restrictions.
* Not presence of clinically significant and relevant abnormalities of clinical history or oral examination.
* Diagnosis of normal pulp or reversible pulpitis.
* No presence of periapical periodontitis
* Posterior teeth

Exclusion Criteria:

General: Patients with systemic diseases, diabetes, immunocompromised and pregnant women, or any clinically significant or relevant oral abnormalities.

Specific: Impossibility of restoration, diagnosis of irreversible pulpitis or necrosis, preoperative pain

Where this trial is running

Sant Cugat del Vallès, Barcelona

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Dental CariesDental MaterialsDental cariesDental materialsOutcomePostoperative Pain
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.