Seeing Diabetes Clearly: multi-organ MRI of organ health in adults with type 2 diabetes
UK Imaging Diabetes Study Seeing Diabetes Clearly
This project will use a detailed abdominal and multi-organ MRI plus blood and urine tests to see if imaging measurements can predict future health events in adults with type 2 diabetes who have not had heart disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Perspectum Industry-sponsored |
| Locations | 12 sites (Didcot, Oxfordshire and 11 other locations) |
| Trial ID | NCT05057403 on ClinicalTrials.gov |
What this trial studies
This is a prospective, observational cohort carried out at multiple UK sites where participants undergo one baseline visit with medical history, anthropometrics and blood/urine sampling, and a second visit for a multiparametric multi-organ MRI scan within 28 days. No change to standard care is made; the MRI and biomarker data are collected once and linked to routine NHS medical records for up to five years to capture hospital admissions and mortality. The aim is to correlate MRI-derived organ health metrics with later clinical events to characterise disease progression. Enrollment is limited to adults with type 2 diabetes without a recent cardiovascular event and who can safely undergo MRI.
Who should consider this trial
Good fit: Adults aged 18 or older with type 2 diabetes, no history of cardiovascular events in the prior 12 months, and who can safely undergo MRI are ideal candidates.
Not a fit: People with recent cardiovascular events, standard MRI contraindications (for example pacemaker, pregnancy, severe claustrophobia), known significant liver or renal structural disease, or alcohol dependency are not eligible and are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, MRI-derived markers could help identify people with type 2 diabetes at higher risk of complications earlier, enabling closer monitoring or targeted prevention.
How similar studies have performed: Previous imaging work has linked individual MRI measures (such as liver fat and cardiac imaging) to metabolic risk, but using a coordinated multi-organ MRI to predict long-term clinical events in type 2 diabetes is relatively novel and not yet proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female at least 18 years of age and diagnosed with type 2 diabetes, with or without diabetic retinopathy. * Participant willing and able to give informed consent for participation in the study. Exclusion Criteria: In 12 months prior to consent, evidence of existing cardiovascular event defined as at least one of: * myocardial infarction * ischaemic stroke * hospital admission/discharge for unstable angina * heart surgery * unstable angina * transient ischemic attack * The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MR exclusion criteria including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia). * Patients with known autoimmune hepatitis, viral hepatitis, Wilson's disease or known significant structural renal tract abnormality. * Patients with known alcohol dependency. * Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study
Where this trial is running
Didcot, Oxfordshire and 11 other locations
- Woodlands Medical Centre — Didcot, Oxfordshire, United Kingdom (Recruiting)
- Eynsham Medical Centre — Eynsham, Oxfordshire, United Kingdom (Recruiting)
- White Horse Medical Practice — Farringdon, Oxfordshire, United Kingdom (Recruiting)
- Windrush Medical Practice — Witney, Oxfordshire, United Kingdom (Recruiting)
- The House Partnership — Redhill, Surrey, United Kingdom (Recruiting)
- Swansea Bay University Health Board — Baglan, Swansea, United Kingdom (Not_yet_recruiting)
- University Hospitals of Liverpool Group — Liverpool, United Kingdom (Recruiting)
- Moorfields Eye Hospital NHS Foundation Trust — London, United Kingdom (Enrolling_by_invitation)
- The Manor Group — Oxford, United Kingdom (Recruiting)
- Hedena Health — Oxford, United Kingdom (Recruiting)
- St Bartholomew and Hollow Way Medical Practice — Oxford, United Kingdom (Recruiting)
- Oxford Community Diagnostic centre — Oxford, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Ravi Pattanshetty — Perspectum
- Study coordinator: Soubera Rymall, MSc
- Email: soubera.rymell@perspectum.com
- Phone: 00447919272482
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.