Seeing Diabetes Clearly: multi-organ MRI of organ health in adults with type 2 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational cohort carried out at multiple UK sites where participants undergo one baseline visit with medical history, anthropometrics and blood/urine sampling, and a second visit for a multiparametric multi-organ MRI scan within 28 days. No change to standard care is made; the MRI and biomarker data are collected once and linked to routine NHS medical records for up to five years to capture hospital admissions and mortality. The aim is to correlate MRI-derived organ health metrics with later clinical events to characterise disease progression. Enrollment is limited to adults with type 2 diabetes without a recent cardiovascular event and who can safely undergo MRI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female at least 18 years of age and diagnosed with type 2 diabetes, with or without diabetic retinopathy.
* Participant willing and able to give informed consent for participation in the study.

Exclusion Criteria:

In 12 months prior to consent, evidence of existing cardiovascular event defined as at least one of:

* myocardial infarction
* ischaemic stroke
* hospital admission/discharge for unstable angina
* heart surgery
* unstable angina
* transient ischemic attack
* The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MR exclusion criteria including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).
* Patients with known autoimmune hepatitis, viral hepatitis, Wilson's disease or known significant structural renal tract abnormality.
* Patients with known alcohol dependency.
* Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study

Where it's running

• Woodlands Medical Centre
  Didcot, Oxfordshire, United Kingdom Recruiting
• Eynsham Medical Centre
  Eynsham, Oxfordshire, United Kingdom Recruiting
• White Horse Medical Practice
  Farringdon, Oxfordshire, United Kingdom Recruiting
• Windrush Medical Practice
  Witney, Oxfordshire, United Kingdom Recruiting
• The House Partnership
  Redhill, Surrey, United Kingdom Recruiting
• University Hospitals of Liverpool Group
  Liverpool, United Kingdom Recruiting

Study contacts

• Principal investigator: Ravi Pattanshetty — Perspectum
• Study coordinator: Soubera Rymall, MSc
• Email: soubera.rymell@perspectum.com
• Phone: 00447919272482

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.