Screening program for early detection of Type 1 Diabetes in high-risk children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to implement a screening program for Type 1 Diabetes (T1D) in children who have a first-degree relative diagnosed with the condition. The program focuses on identifying genetic and immunological markers that indicate a high risk for developing T1D, allowing for early intervention and education on symptom awareness. By screening for islet autoantibodies, HLA phenotypes, and genetic risk scores, the study seeks to improve early detection and potentially delay the onset of T1D in this vulnerable population. The initiative addresses the lack of established screening programs in Saudi Arabia, where T1D incidence is notably high.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* T1D diagnosis in a first-degree relative:

Diabetes is defined based on the American diabetes association (ADA) definition: Classic symptoms of diabetes or hyperglycemic crisis, with plasma glucose concentration ≥11.1 mmol/L (200 mg/dL), or Fasting plasma glucose ≥7.0 mmol/L (≥126 mg/dL). Fasting is defined as no caloric intake for at least 8 h, or Two-hour post load glucose ≥11.1 mmol/L (≥200 mg/dL) during an OGTT, or HbA1c \>6.5%.

Exclusion Criteria:

* first-degree relative case with Maturity-Onset Diabetes of the Young (MODY) or Type 2 Diabetes Mellitus (T2DM).
* Non-Saudi children.
* first-degree relative not following at our centre.

Where it's running

• The University Diabetes Centre at King Saud University Medial CIty
  Riyadh, Saudi Arabia Recruiting

Study contacts

• Study coordinator: Modi Alrashid
• Email: ralkhalifah@ksu.edu.sa
• Phone: +966555834797

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.