Screening program for Asian female nonsmokers at risk for lung cancer
Female Asian Nonsmoker Screening Study (FANSS)
This study is trying to see if regular low-dose CT scans and blood tests can help find lung cancer earlier in Asian women who have never smoked but are still at higher risk.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 40 Years to 74 Years |
| Sex | Female |
| Sponsor | NYU Langone Health Academic / other |
| Locations | 1 site (New York, New York) |
| Trial ID | NCT05164757 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a database and biorepository specifically for Asian female never smokers, who are at a heightened risk for lung cancer despite not meeting current screening criteria. Participants aged 40-74 will undergo up to three low-dose CT scans and provide blood samples for a cancer detection assay. The study will also collect clinical, demographic, and exposure history data, including potential exposure to the World Trade Center (WTC). The goal is to enhance early detection strategies for lung cancer in this underserved population.
Who should consider this trial
Good fit: Ideal candidates are Asian females aged 40-74 who have never smoked and have no prior history of lung cancer.
Not a fit: Patients with a history of lung cancer or current symptoms suggestive of lung cancer will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection of lung cancer in Asian female nonsmokers, potentially saving lives.
How similar studies have performed: While there may be limited studies focusing specifically on this demographic, the approach of using low-dose CT scans for early detection in high-risk groups has shown promise in other populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 40-74 years * Female * Never Smoker defined as a lifetime exposure of less than 100 cigarettes * Identify as from Asian descent, defined as having reported ancestry or race from the continent of Asia. Individuals with mixed heritage are eligible. Exclusion Criteria: * Prior history of lung cancer. * Treatment for, or advisement by a physician of evidence of any cancer within the past five years, with the exceptions of non-melanoma skin cancer and most in-situ carcinomas based on PI discretion. (Treatment for, or evidence of, melanoma or in-situ bladder/transition cell carcinomas within the preceding five years renders the potential participant ineligible.) * Participation in a cancer prevention trial. * Present symptoms suggestive of current lung cancer, including: unexplained weight loss of over 15 pounds within the 12 months or unexplained hemoptysis. * Medical or psychiatric condition precluding informed medical consent. * Pneumonia or acute respiratory infection within 12 weeks of enrollment that was treated with antibiotics under physician supervision.
Where this trial is running
New York, New York
- NYU Langone Health — New York, New York, United States (Recruiting)
Study contacts
- Principal investigator: Elaine Shum, MD — NYU Langone Health
- Study coordinator: Elaine Shum, MD
- Email: FANSS@nyulangone.org
- Phone: 212-731-6212
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.