Screening individuals at risk for malignant hyperthermia
Official title: Molecular Genetics Study on Screening of Malignant Hyperthermia Susceptible Individuals
Run by Peking University Third Hospital · NCT05402839 · Data updated 2026-11-12
This study is trying to find out more about the genes that might cause malignant hyperthermia by collecting samples from patients who have had this reaction during surgery and their family members.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 0 Years to 100 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | February 22, 2022 |
| Main results expected | February 2041 |
| Study ends | February 2041 |
| Registry record updated | June 2, 2022 |
| Trial ID | NCT05402839 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients who developed malignant hyperthermia during or after surgery under general anesthesia.
✕Probably not a fit
Patients who have been ruled out for malignant hyperthermia through subsequent treatment and diagnosis will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients who experienced malignant hyperthermia during or after surgery under general anesthesia. It aims to collect genetic specimens from these patients and their family members to analyze mutations related to malignant hyperthermia. The study anticipates enrolling approximately 50 participants nationwide, with 1-5 patients from Peking University Third Hospital. The goal is to better understand the genetic factors contributing to this rare condition.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of malignant hyperthermia and lead to improved screening and management strategies for at-risk individuals.
How similar studies have gone: While there have been studies on malignant hyperthermia, this specific genetic screening approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing surgery under general anesthesia during the study period developed malignant hyperthermia during or after surgery. Exclusion Criteria: * Malignant hyperthermia was ruled out by later treatment and diagnosis; * The patient or family member refuses to be recruited.
Where it's running
-
Peking University Third Hospital
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Yinyin Qu, M.D.
- Email: quyinyin@bjmu.edu.cn
- Phone: +8613466759889
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.