Screening for lung cancer in individuals with a family history of the disease
Screening for Lung Cancer in Subjects With Family History of Lung Cancer
This study is testing if screening family members of lung cancer patients with low-dose CT scans can help find lung cancer early, especially in women who have never smoked.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1520 (estimated) |
| Ages | 50 Years to 75 Years |
| Sex | All |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT05762731 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the rate of lung cancer detection in individuals who are first-degree relatives of lung cancer patients. It will involve screening 1,520 participants using low-dose computed tomography (LDCT) of the thorax, along with detailed questionnaires to gather relevant health information. The study seeks to identify early-stage lung cancer in this high-risk group, particularly focusing on the unique demographic of female never-smokers in Hong Kong. The primary outcome will be the number of lung cancers detected through this screening process.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 50-75 who are first-degree relatives of lung cancer patients, regardless of their smoking status.
Not a fit: Patients who are non-Chinese or those who have known lung cancer prior to the study will not benefit from this screening.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of lung cancer in individuals with a family history, potentially improving survival rates.
How similar studies have performed: Previous studies have shown success in lung cancer screening using LDCT in high-risk populations, but this specific approach focusing on family history is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 50-75, men or women, smokers or non-smokers * Being first degree relatives (Siblings, children, and parents) of lung cancer subjects * Having no known lung cancer before Exclusion Criteria: * Non-Chinese * Mentally incompetent to give informed consent
Where this trial is running
Hong Kong
- University of Hong Kong — Hong Kong, Hong Kong (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.