Screening for cervical pre-cancer and cancer prevention in South African women
Primary HPV Screening as an Indicator of Cervical Pre-invasive and Invasive Neoplasia in HIV-positive and -Negative Southern African Women
This study is testing new ways to screen for cervical pre-cancer and cancer in South African women to help catch the disease early and improve prevention efforts.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1500 (estimated) |
| Ages | 25 Years to 75 Years |
| Sex | Female |
| Sponsor | University of Pretoria Academic / other |
| Locations | 1 site (Pretoria, Gauteng) |
| Trial ID | NCT02956031 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the prevalence of cervical pre-cancer and cancer among women in South Africa, where cervical cancer remains a significant health issue. It focuses on improving screening methods, particularly through the use of HPV testing, to enhance early detection and prevention strategies. Participants will undergo cervical cytology screening, colposcopy, and LLETZ procedures as necessary, with the goal of identifying undiagnosed cases of cervical disease. The study seeks to gather data that could inform better screening practices and ultimately reduce cervical cancer incidence.
Who should consider this trial
Good fit: Ideal candidates for this study are women seeking cervical cancer screening who are willing to participate in the testing process.
Not a fit: Patients who are currently pregnant, have had a hysterectomy, or have a history of gynaecological cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved cervical cancer screening and prevention strategies, potentially saving lives.
How similar studies have performed: Other studies have shown success with similar HPV screening approaches, indicating potential for effective cervical cancer prevention.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed consent accepted and signed * Health seeking behaviour or request for a cervical cancer screening test * Willing and able to receive test result by automated text message or clinic visit Exclusion Criteria: * Current pregnancy * Hysterectomy * Current or previous treatment for gynaecological cancer * Hesitant or unable to undergo screening and treatment if indicated
Where this trial is running
Pretoria, Gauteng
- Steve Biko Academic Hospital — Pretoria, Gauteng, South Africa (Recruiting)
Study contacts
- Principal investigator: Greta D Dreyer, PhD — University of Pretoria
- Study coordinator: Greta Dreyer, PhD
- Email: greta.dreyer@up.ac.za
- Phone: +(27) 12 354 3900
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.