Screening children for early signs of Type 1 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to screen children aged 9 months to 5 years across Israel for the presence of islet autoantibodies, which are indicators of pre-symptomatic Type 1 diabetes mellitus. Up to 50,000 children will be tested by their primary care physicians, with initial screenings conducted at age 1 and repeated until age 5. The study utilizes an innovative technology called Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP) to measure antibodies in capillary blood samples, allowing for earlier detection than current methods. Positive results will be confirmed with additional samples analyzed by the same technology and a radio-binding assay for further validation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Informed consent obtained before any trial-related activities
* Children aged 9-months- 5 years at first screening.

Exclusion Criteria:

* Known diagnosis of diabetes (Type 1 or other)

Where it's running

• Soroka Medical Center
  Beersheba, Israel Recruiting
• Child Health Centers all over Israel (clalit Health Services)
  Petah Tikva, Israel Recruiting
• Schneider Children Medical Center of Israel
  Petah Tikva, Israel Recruiting
• Rambam Medical Center
  Haifa, Israel Not yet recruiting
• Hadassah medical Center
  Jerusalem, Israel Not yet recruiting
• Sheba Medical Center
  Ramat Gan, Israel Not yet recruiting

Study contacts

• Study coordinator: Moshe Phillip, Prof
• Email: moshe.phillip@phillipmd.com
• Phone: 972-544-795-995

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• New real-time continuous glucose monitor accuracy and safety in adults with type 1 diabetes

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.