School-centered prevention program for latent rheumatic heart disease in children
Official title: Effectiveness of a School-centered Primary and Secondary Prevention Program on Prevalence of Latent Rheumatic Heart Disease
Run by Insel Gruppe AG, University Hospital Bern · NCT05504928 · Data updated 2026-11-12
This study is testing a school program in Nepal to see if it can help find and treat throat infections early to prevent heart problems in children aged 5 to 16.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 5 Years to 16 Years |
| Sex | All |
| Enrollment | 2300 (estimated) |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 1 site (Tulsi̇̄pur) |
| Status | Recruiting |
| Started | June 1, 2022 |
| Main results expected | June 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | August 17, 2022 |
| Trial ID | NCT05504928 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children aged 5-16 years who attend Tulsi Secondary Boarding School in Tulsipur, Nepal.
✕Probably not a fit
Patients who do not attend Tulsi Secondary Boarding School or those whose caregivers do not provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of a school-centered prevention program aimed at reducing the prevalence of latent rheumatic heart disease among schoolchildren in Nepal. It focuses on timely detection and treatment of group A β-hemolytic streptococcal pharyngitis using rapid antigen detection tests, followed by antibiotic prophylaxis. The program also investigates the influence of socioeconomic and environmental factors on the disease's development and progression. Children aged 5-16 years attending Tulsi Secondary Boarding School will be included in the study, which employs an interrupted time series design to assess outcomes.
Why it matters
Potential benefit: If successful, this program could significantly reduce the incidence of rheumatic heart disease in children, improving long-term health outcomes.
How similar studies have gone: Other studies have shown success with school-centered health interventions in reducing disease prevalence, suggesting a promising approach for this program.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 5-16 years * Attending Tulsi Secondary Boarding School in Tulsipur, Nepal. Exclusion Criteria: * Children / primary caregivers not providing informed consent to participate * Children not attending Tulsi Secondary Boarding School in Tulsipur.
Where it's running
-
Tulsi Secondary Boarding School
Tulsi̇̄pur, Nepal Recruiting
Study contacts
- Principal investigator: Thomas Pilgrim, Prof. Dr. — Bern University Hospital
- Study coordinator: Thomas Pilgrim, Prof. Dr.
- Email: kardio.studien@insel.ch
- Phone: 0041316325000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study tests a school-based nurse program and awareness effort to help children with latent rheumatic heart disease in three countries.
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School-based program to prevent rheumatic heart disease in children in endemic regions
The program will try to prevent rheumatic heart disease in schoolchildren aged 5–16 by placing trained nurses in schools to teach about strep throat, provide assessment and treatment, and help ensure ongoing antibiotic prevention for those at risk.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.