School-centered prevention program for latent rheumatic heart disease in children
Effectiveness of a School-centered Primary and Secondary Prevention Program on Prevalence of Latent Rheumatic Heart Disease
This study is testing a school program in Nepal to see if it can help find and treat throat infections early to prevent heart problems in children aged 5 to 16.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 2300 (estimated) |
| Ages | 5 Years to 16 Years |
| Sex | All |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Locations | 1 site (Tulsi̇̄pur) |
| Trial ID | NCT05504928 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a school-centered prevention program aimed at reducing the prevalence of latent rheumatic heart disease among schoolchildren in Nepal. It focuses on timely detection and treatment of group A β-hemolytic streptococcal pharyngitis using rapid antigen detection tests, followed by antibiotic prophylaxis. The program also investigates the influence of socioeconomic and environmental factors on the disease's development and progression. Children aged 5-16 years attending Tulsi Secondary Boarding School will be included in the study, which employs an interrupted time series design to assess outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 5-16 years who attend Tulsi Secondary Boarding School in Tulsipur, Nepal.
Not a fit: Patients who do not attend Tulsi Secondary Boarding School or those whose caregivers do not provide informed consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly reduce the incidence of rheumatic heart disease in children, improving long-term health outcomes.
How similar studies have performed: Other studies have shown success with school-centered health interventions in reducing disease prevalence, suggesting a promising approach for this program.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 5-16 years * Attending Tulsi Secondary Boarding School in Tulsipur, Nepal. Exclusion Criteria: * Children / primary caregivers not providing informed consent to participate * Children not attending Tulsi Secondary Boarding School in Tulsipur.
Where this trial is running
Tulsi̇̄pur
- Tulsi Secondary Boarding School — Tulsi̇̄pur, Nepal (Recruiting)
Study contacts
- Principal investigator: Thomas Pilgrim, Prof. Dr. — Bern University Hospital
- Study coordinator: Thomas Pilgrim, Prof. Dr.
- Email: kardio.studien@insel.ch
- Phone: 0041316325000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.