Saliva test for molecules linked to emotional responses
Official title: Evaluation of Emotion-related Salivary Molecular Biomarkers Following Olfactory Stimuli
Run by Sys2Diag · NCT07320040 · Data updated 2026-11-12
This project will test whether a quick saliva test can detect chemical changes tied to emotions after people smell different scents, in adults aged 18–60.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | Sys2Diag Government |
| Locations | 1 site (Montpellier) |
| Status | Recruiting |
| Started | November 14, 2022 |
| Main results expected | March 14, 2023 |
| Study ends | June 14, 2027 |
| Registry record updated | January 29, 2026 |
| Trial ID | NCT07320040 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 who can give informed consent, are willing to undergo olfactory testing, and do not have anosmia, active oral inflammation, or excluded infectious conditions.
✕Probably not a fit
People who are minors, deprived of liberty or otherwise legally vulnerable, have recent anosmia, active oral disease, or chronic infectious conditions affecting sample handling are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study collects non-invasive saliva samples before and after one or more standardized olfactory stimuli to measure enzymes and hormones such as cortisol and alpha-amylase. Molecular concentrations will be quantified and analyzed to identify a signature pattern associated with positive or negative emotional states. Participants aged 18–60 who can consent will be screened for oral health and infectious risks to ensure sample safety. The aim is to correlate salivary biomarker changes with subjective emotional responses to build a reproducible molecular profile.
Why it matters
Potential benefit: If successful, the work could lead to a simple, non-invasive saliva test that provides objective information about a person's emotional state.
How similar studies have gone: Prior research has shown that salivary markers like cortisol and alpha-amylase change with emotion, but a validated, clinically usable molecular signature tied to olfactory stimuli is not yet established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subject willing to follow study procedures * Subject able to understand the purpose, nature and methodology of the study * Subject has signed informed consent form * Subjects between 18 and 60 years of age. Exclusion Criteria: * Subjects deprived of liberty, protected adults, vulnerable persons or minors * Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample) * Rejection to sign the consent form. Non specific inclusion criteria: * Pregnant or breastfeeding women * Subjects presenting anosmia during the last 15 days * Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis.
Where it's running
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SYS2DIAG - UMR9005 CNRS/ALCEN, Montpellier, 34184
Montpellier, France Recruiting
Study contacts
- Principal investigator: Laurence MOLINA, Phd — Sys2Diag
- Study coordinator: Wendpouiré A OUEDRAOGO, Msc
- Email: alimata.ouedraogo@sys2diag.cnrs.fr
- Phone: +33 (0) 467 047 481
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.