Saliva biomarkers to help detect sport-related concussion
Official title: Determination of the Physiological Profile and Evaluation of the Effect of Intense Physical Exertion Among Professional Athletes
Run by Sys2Diag · NCT06149351 · Data updated 2026-11-12
This project will test whether saliva biomarkers can help detect sport-related concussion in men aged 18 to 50.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | Men only |
| Enrollment | 80 (estimated) |
| Sponsor | Sys2Diag Government |
| Locations | 1 site (Montpellier) |
| Status | Recruiting |
| Started | December 12, 2023 |
| Main results expected | June 12, 2026 |
| Study ends | December 12, 2027 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT06149351 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are male athletes aged 18–50 who are affiliated with the French social security system, able to consent, and willing to provide saliva samples at the Montpellier site.
✕Probably not a fit
People who are female, younger than 18 or older than 50, not affiliated with the French social security system, legally protected or deprived of liberty, or with disqualifying infectious conditions are not eligible and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study collecting saliva samples to measure protein and nucleic acid biomarkers linked to sport-related concussion. Researchers will establish normal (reference) biomarker profiles in healthy athletes and document how those levels change after concussion. Samples will be analyzed using bio-fluid assays at the Montpellier site in collaboration with CNRS to support development of a diagnostic test. Participants are adult males who meet inclusion criteria and can provide informed non-opposition consent.
Why it matters
Potential benefit: If successful, the work could enable a simple, noninvasive saliva test to help diagnose sport-related concussion more reliably and quickly.
How similar studies have gone: Previous research has identified candidate salivary biomarkers in athletes, but reference ranges and robust validation for diagnostic use remain incomplete.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male participants aged between 18 and 50 years old. * Participants willing to comply with the study procedures. * Participants capable of understanding the purpose, nature, and methodology of the study. * Participants affiliated to a French social security system or beneficiaries of such a system. * Participants who have signed the non-opposition form to participate in the research. Non-inclusion Criteria: * Participant not affiliated to a French social security system or not a beneficiary of such a system. * Participants deprived of liberty, protected adults, vulnerable individuals, or minors. * Participants with a proven or suspected chronic infectious disease that may introduce a risk of contamination during sample handling (laboratories not equipped to handle this type of sample). * Refusal to sign the non-opposition form to participate in the research. Non-inclusion specific criteria * Subject who has had a recent stroke or epilepsy event (within the past two months). * Subject suffering from neurological diseases.
Where it's running
-
Sys2Diag - Umr9005 Cnrs/Alcen
Montpellier, France Recruiting
Study contacts
- Principal investigator: Thi Nhu Ngoc VAN, Phd — Sys2Diag
- Study coordinator: Wendpouiré A OUEDRAOGO, Msc
- Email: alimata.ouedraogo@sys2diag.cnrs.fr
- Phone: +33 (0) 467 047 481
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Linking head accelerations to saliva concussion markers in French U20 rugby players
We will try to see if saliva micro-RNAs and other biomarkers change after head impacts recorded by instrumented mouthguards in male French under-20 rugby players.
-
Saliva test for molecules linked to emotional responses
This project will test whether a quick saliva test can detect chemical changes tied to emotions after people smell different scents, in adults aged 18–60.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.